Discover and read the best of Twitter Threads about #microrounds

Most recents (2)

Thoughts on upcoming #COVID19 #serology tests:
This is actually quite a challenge! (#Diagnostics often involve a lot of complexities). There is a lot of pressure to roll these tests out, but they need to perform well, or we do more harm than good. #MicroRounds (A thread)
WHY we need these soon:
1. Contact tracing.
2. Can be used to test if a vaccine is working during a clinical trial (70 of them ongoing right now, I believe)
3. Inform public policy makers about rate of asymptomatic cases + previous infections/exposures =informed decision making
How is developing a #PCR different than developing a #serology test?
1. #PCR tests detect viral RNA/DNA (in this case RNA) and can be pretty straight-forward in terms of development
2. #Serology relies on knowing about the #SARSCoV2 structure and how the human body responds.
Read 13 tweets
1/ Yday on micro rounds we discussed Group A streptococcus (GAS). We briefly touched on the rationale behind using adjunctive clindamycin for severe forms of invasive GAS. So here is a short tweetorial on the topic. @CarlosdelRio7 @Dr_AmyKacin @colleenkraftmd
2/ GAS is an aerobic GPC. GAS invasive disease (iGAS) is defined by isolation of GAS from a normally sterile body site. The most severe of these invasive disease entities are generally thought to be necrotizing fasciitis (NF) and streptococcal toxic shock syndrome (STSS).
3/ Currently, the addition of clindamycin therapy to B-lactams and surgical debridement is recommended by the IDSA for Necrotizing fasciitis and used routinely in management of STSS, despite low rates of PCN resistance . What is the rationale?

doi.org/10.1093/cid/ci…
Read 11 tweets

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