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PAPER OUT !! 🎉🥂🍾 @Nature
nature.com/articles/s4158…
Viral restrictor APOBEC3A is a major cause of mutational signatures found in >50% of cancers + more, Tweetorial👇
With @J_Maciejowski
Via WGS/251 cancer clones (available!)
@broadinstitute
@MSKCancerCenter
@sangerinstitute
nature.com/articles/s4158…
Viral restrictor APOBEC3A is a major cause of mutational signatures found in >50% of cancers + more, Tweetorial👇
With @J_Maciejowski
Via WGS/251 cancer clones (available!)
@broadinstitute
@MSKCancerCenter
@sangerinstitute
The APOBEC family of cytosine deaminases has been implicated as a source of some of the most prevalent mutational signatures in cancer. BUT, causal links between endogenous APOBECs and mutations in cancer haven’t been established, leaving the mechanisms poorly understood.
To investigate the mechanisms underlying acquisition of APOBEC-associated mutational signatures in cancer, we deleted implicated genes from human cancer cell lines that we previously showed generate the relevant signatures naturally over time (cell.com/cell/pdf/S0092…)
