Discover and read the best of Twitter Threads about #mitochondrialcollapse
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Key: "The observed pulmonary vascular dilation might be due to relative failure of normal, physiological hypoxic pulmonary vasoconstriction in the setting of overactivation of a regional vasodilatation cascade as part of a dysfunctional and diffuse inflammatory process." 2/
This leads me to hypothesize this is the site of viral injury, where #COVID binds #ACE2R's - where mito demands are the greatest - where #HIF proteins and assoc. cascades they initiate are in play - including #vasodialiation #angiogenesis and excessive #inflammation 3/
