Discover and read the best of Twitter Threads about #mitophagy
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🎉New preprint! @LauraKremer20 and I looked at four different gene knockouts in mt.5024C>T mice to investigate how #autophagy affects #mtDNA heteroplasmy inheritance. biorxiv.org/content/10.110…
@MRC_MBU @cam_mito @mitopinionated 🧵: 1/
@MRC_MBU @cam_mito @mitopinionated 🧵: 1/
To what extent is germline purifying selection driven by autophagy? We looked at the mother-to-pup heteroplasmy shift in high-heteroplasmy mice carrying Parkin, Bcl2l13, Ulk1, and Ulk2 knockouts, as well as two separate control populations. 2/ 
While previously Filograna et al. (2019) @RobertaFilogra2 show TFAM overexpression can lead to higher maximal tolerated heteroplasmy, this was not the case for our autophagy knockouts. We saw no knockout mice with H>80%, despite having 120+ pups in each group. 3/
Very excited to share our recent article on the effects of dietary #spermidine (SPD) on neuronal #mitochondria and cognition during #aging. Out this week in @Cell_reports tinyurl.com/ha2n9h5z. This marks my 2nd co-first research article from my PhD time. A long thread 1/12
After a crazy 1.5 years revision during a global pandemic finally time to celebrate. Take-away for PhD students in aging research: you'll age with your project. Specifically aging + behavior tests = never-ending experiments and lots of new grey hair. 2/12 #AcademicTwitter
It was worth it, though! We analysed the effects of dietary SPD on neuronal mitochondria. In cardiac tissue this was reported by @EisenbergTobias in @NatureMedicine tinyurl.com/tc7hkxja. Using @OroborosI respirometers we showed increased respiration in flies and mice 3/12
