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Ever felt your favorite gene has *more than one function* after perturbing it in many cell contexts? Today at #MLCB2021, I'll discuss automatic genotype-phenotype inference from high-dimensional gene perturbation data using sparse approximation: arxiv.org/abs/2111.06247 [a 🧵] 
This work was performed with my mentors @marinkazitnik (@HarvardDBMI), James McFarland (@CancerDepMap), and William Hahn (@broadinstitute @DanaFarber)
along with @JKwonBio, Jessica Talamas, @AshirBorah, @aviadt, @paquita, @boehmjesse
along with @JKwonBio, Jessica Talamas, @AshirBorah, @aviadt, @paquita, @boehmjesse
Words and genes share a correspondence: their *meanings* are resolved via context. Just as polysemic works like "apple" can refer to fruits or computers depending on the sentence, pleiotropic genes can perform function_1 or function_2 depending on what's going on in the cell.
