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Happy present our manuscript on targeting RTK and adaptive resistance in RTK-addicted sarcomas 🎯. @MLadanyi, Romel Somwar and amazing @sloan_kettering pediatrics team! @JGladeBender @MichaelVOrtiz #MSKkids #MolPath #Sarcoma @OncoAlert
cancerres.aacrjournals.org/content/early/…
🧵 🧵 🧵 (1/19)
cancerres.aacrjournals.org/content/early/…
🧵 🧵 🧵 (1/19)
Disclaimer #1: I have no conflicts of interest to disclose.
Disclaimer #2: Please note that this post does not constitute medical advice. Please consult your physician or other qualified health care provider. (2/19)
Disclaimer #2: Please note that this post does not constitute medical advice. Please consult your physician or other qualified health care provider. (2/19)
With the development and broader adaptation of NGS, we now know that a variety of soft tissue sarcomas harbor receptor tyrosine kinase (RTK) fusions. (3/19)
1/This is very basic but might be useful at a certain point...so the basic question is how do you check quickly for the prevalence of a mutation in your favorite cancer type...my question was: How often do we find NRAS mutation in malignant melanoma?
#pathology #molpath
#pathology #molpath
2/ The question comes from an article on 14 melanoma cases that were found to be S100 and Sox10 negative. The authors found that the overall frequency of NRAS mutations in this small cohort was 36%. So as a first step I go to the cbioportal.org homepage
3/ In the "Search" field I type "melanoma"
