Discover and read the best of Twitter Threads about #monoclonalab
Most recents (1)
With #Omicron rapidly spreading nationwide, I am concerned about all the members of our communities with damage and injury in the immune system, particularly to cell-mediated injury (to T cells and Ab-producing cells). In neutralization studies, most monoclonal Abs used to date
2/ have lost activity to #Omicron and are no longer useful in areas with high attack rates (pretty much everywhere in US right now). There are two possible exceptions. The first is #sotrovimab which was originally isolated from an individual with
3/ #SARSCoV1 (not a typo) back in 2003. The Ab recognizes a conserved glycan motif at the base of the Spike protein (away from the ACE-2 receptor-binding domain). Extremely limited supplies and fairly narrow emergency use authorization, as follows:
