Discover and read the best of Twitter Threads about #monoclonalantibodies

Most recents (11)

Broadly acting Mabs effective against #Omicron & Omicron+R346K are in development including STI-9167 from Sorrento (now in Phase 2) licensed from @IcahnMountSinai. Impressive groundwork by Drs. Domenico Tortorella (@DomTortorella) and Andy Duty. bit.ly/3IBFnnv see 🧵
#Omicron #MAbs Initial work: No multinational consortium, no multimillion company funded work, shoe-string budget but clever use of (A) Human H2L2 (Harbour Mice ®), (B) RBD-targeted design, and (C) Stringent 1º (binding) and 2º (neutralization) screen via rVSV-CoV2-spike (WA1)
#Omicron #MAbs Initial work: No multinational consortium, no multimillion company funded work, shoe-string budget but clever use of (A) Human H2L2 (Harbour Mice ®), (B) RBD-targeted design, and (C) Stringent 1º (binding) and 2º (neutralization) screen via rVSV-CoV2-spike (WA1)
Read 7 tweets
Of course it does.

But you won't find any "#GoodDoctors" promoting this, as it is synthetic drugs or nothing.

Captured agencies.

Captured doctors.

#ConformingNonConformists to a person.

They max out at around 5K RXs a year at $50+ per RX.

They are having their best years.
Instead of replicating their success and using a tip jar approach where I and other create lead-gen funnels for the entire network and the make certain the max out at an affordable price they just max out individually and call it a day.

That's not a scaled approach, that's a...
Selfish narrow-minded approach. They could have thousands of cannabis patients using safe &effective tinctures and other natural remedies IN ADDITION to their indoctrinated synthetic drugs, but they're not even open to that discussion.

They won't demand #HCQ and #IVM be made...
Read 25 tweets
The fact that tRump is not in jail just showsour failed system of govt and justice.

There is not one single "average" American who believes if they stole $6.2 Trillion! or funneled money illegally through fake charities or lied publicly while people died wouldnt be in jail.
BUT WAIT THERE'S MORE!

The fact that Biden picked up right where Fauci, err, sorry tRump left off, would make him an accomplice and an average American would be rounded up and thrown in jail without bail as well.

Fellow Americans we can't have it both ways ANYMORE.
We're killing ourselves by allowing EITHER party to get away with these crimes.

It is time we all #StandUp and refuse to allow elections until they are ALL disqualified from running.

FUCK them. This is our time to demand #PublicService.

$6.2 TRILLION and look at the shithole
Read 12 tweets
Daily Bookmarks to GAVNet 12/29/2021 greeneracresvaluenetwork.wordpress.com/2021/12/29/dai…
Someone in my home has COVID. How do we isolate safely? - Clean Air Crew

cleanaircrew.org/someone-in-my-…

#COVID19, #IsolationAtHome, #TransmissionRisk, #HouseholdMembers
Differences Between a Secular and a Religious Upbringing

dailysignal.com/2021/12/14/dif…

#SecularUpbringing, #ReligiousUpbringing, #ValueSystems, #differences
Read 15 tweets
Daily Bookmarks to GAVNet 12/20/2021 greeneracresvaluenetwork.wordpress.com/2021/12/20/dai…
Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA

science.org/doi/10.1126/sc…

#ImmunoGlobulinA, #AntiviralImmunity, #RespiratorySystem, #VaccineEfficacy, #ResearchReport
Bizarre tail weaponry in a transitional ankylosaur from subantarctic Chile | Nature Portfolio Ecology & Evolution Community

ecoevocommunity.nature.com/posts/bizarre-…

#paleontology, #ChileanPatagonia, #FossilDiscovery, #ankylosaur, #PublicationBackground
Read 20 tweets
The Biden administration left us with more questions than answers yesterday RE: throttling antibody treatments. We were told HHS began rationing to “prevent a run on the bank,” but when asked - TWICE - for data on current supply… (1/3) #HHSRationing #MonoclonalAntibodies
…& manufacturing capacity then compared to demand… crickets. So now Texas treatments are cut in half. HHS is acting as a barrier to providers who need these life-saving treatments - saying specifically that 7 states were causing an unsustainable level of orders. (2/3)
…However, they added that “there is significant product in the field” and offered no clear evidence current shortage.

We will continue to push to know why this decision was made and press to know what are our manufacturing capabilities are. (3/3)
Read 3 tweets
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed. Image
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues. Image
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin. Image
Read 235 tweets
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..." ImageImageImage
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964 ImageImageImageImage
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily. ImageImageImageImage
Read 68 tweets

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