Discover and read the best of Twitter Threads about #monoclonals

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Here goes (today’s) Warren.

1/23
Thanks to Twitter legend brains, who mistakenly call themselves ‘lay people’, Pandora’s box of CFS/ME/Long Covid/Low Cortisol/Adrenals has been opened...

💎

2/23
Inside this box we find:

🧠 Low Cortisol and HypoA


🧠 Anecdotal bilateral adrenal enlargement
@respphysio

🧠 The hypothalamic–pituitary–adrenal (HPA) axis and CFS/ME & LC
@shellchat

🧠 Animals

🧠 Amyloid

3/23
Read 29 tweets
Tabulated the topline results released by the #recoverytrial team on #hydroxychloroquine & #dexamethasone, and went over their protocol (recoverytrial.net/results) to better digest them.

Basic stuff:
- hospitalized patients @ 175 NHS centres
- open label, 5 initial arms
- thread—
Important point from #RECOVERYTrial protocol

- if a patient had a #contraindication to one of the intervention arms, according to the clinical care team at the site, that particular arm was not available to that patient at the time of #randomization
So if a patient enrolled in #recoverytrial had a contraindication to #dexamethasone, that patient was not allowed to be randomized to that arm. So the results need to be interpreted in the context of no contraindication to steroids: already on steroids, #immunosuppression, etc.
Read 11 tweets

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