Discover and read the best of Twitter Threads about #monocytes

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How COVID actively suppresses and evades your immune system [Part 2]

Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/ Image of an AI generated interpretation of a COVID virus rep
An unrolled one-page web view for both parts of this long thread that may be easier to read or share can be found here ( ). 2/
If you haven't read part 1 yet on how the virus hides from T-cells and NK immune cells you can find it here: 3/
Read 29 tweets
How #COVID actively suppresses and evades your immune system [Part 1]

This thread highlights multiple methods that the virus uses to help keep reinfecting people including MHC-I and interferon suppression, evasion of Natural Killer (NK) cells, and reprogramming of monocytes.🧵1/ AI generated image of immun...
An unrolled one-page web view for this long thread that may be easier to read or share can be found here ( ). 2/
COVID has been doing this to varying degrees since the beginning which further reinforces that a vaccine only policy is not enough to stop the cycle of sickness, long term disability, and death. 3/
Read 39 tweets
#Monocytes at the Center of #SARS2 triggered inflammation & severe #Covid19

#SARS2 can cause acute respiratory distress & death in some patients. Although severe #COVID19 disease is linked to exuberant inflammation, how #SARS2 triggers inflammation is not understood. 1/
Monocytes & macrophages are the key sentinel cells that sense invasive infection to form inflammasomes that activate inflammatory cascade by secreting caspase-1 and gasdermin D, leading to inflammatory death (pyroptosis) & release of potent inflammatory mediators. 2/
~6% of monocytes in COVID patients are infected w/ SARS2

Monocyte infection depends on uptake of Ab-opsonized virus by FcÎł receptors

SARS2 begins to replicate in monocytes, but infection is aborted & infectious virus is not detected in infected monocyte culture supernatants. 3/
Read 5 tweets
01/ Vous voulez savoir :
- comment se protéger d’une #COVID sévère sans médicaments sur ordonnance ?
- pourquoi elle touche certaines personnes et pas d'autres ?
- ce qui cause les #EffetsSecondaires des #vaccins ?

#COVID_19 #covid19 #covid #coronavirus #vaccination

02/ Jean-Marc Sabatier (@SabatierJeanMa1), Directeur de Recherche au CNRS depuis 32 ans, PhD/HDR en Biochimie et Microbiologie, nous explique tout cela dans une vidéo ( dont je résume les 42 premières minutes dans ce #thread.
03/ Le virus #SARS-CoV-2 s’attaque au #SRA (le système rénine-angiotensine), un de nos systèmes de régulation les plus importants, responsable des fonctions autonomes rénales, pulmonaires, cardiovasculaires, de l’#immunité innée et du #microbiote intestinal.
Read 48 tweets

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