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#PlantScienceClassics #3: The ligand-induced flg22/FLS2/BAK1 receptor-module. In a 2007 @Nature paper @delphinechinch1 et al. demonstrated that the bacterial flagellin22 triggers the formation of its own receptor-complex in plants, made up of FLS2 & BAK1: doi.org/10.1038/natureā€¦ Cover of the 2007 Nature pa...
Already in 1999/2000, three papers from the legendary Boller-lab @UniBasel in @ThePlantJournal/@MolecularCell identified the elicitor flg22 & its receptor FLS2,laying the groundwork to establish Arabidopsis as a model system to study plant pathogen-interaction & immune-signaling. The three title pages of th...
But it was the addition of BAK1 as co-receptor, and the mechanistic finding that the ligand flg22 induces the formation of its own receptor-complex, which turned the flg22/FLS2/BAK1-module into the platform for countless new discoveries in the #MPMI/#PlantImmunity field. Protein blot from Co-immuno...
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