Discover and read the best of Twitter Threads about #mskimpact
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THREAD: (1/10) Our work in JCO PO looked at NGS data from patients with met lung adeno. Some goals: (1) explore notion of molecular staging (within stage IV) using somatic mut & (2) see what drives poorer outcomes under current standard of care ascopubs.org/doi/full/10.12… #MSKIMPACT 
(2/10) We knew some single-gene mutations were good (e.g. EGFR, ALK) or bad predictive/prognostic determinants. OncoCast helped broadly explore effect of genes & gene combinations using an ensemble statistical learning strategy
(3/10)Some genes like STK11 and KEAP1 came out as neg survival factors on most runs of model. EGFR came out as positive. Interesting to look at the size of effect on survival (KRAS came out a lot, but wasn’t as strong a negative effect as STK11 or KEAP1)
