Discover and read the best of Twitter Threads about #msmm
Most recents (1)
In 2020 with @DrOlaLandgren we revealed how Melphalan has strong mutagenic activity on myeloma cells. This can understandably create fear for patients who have undergone transplant, and we have received many questions from them. Here a thread on what we know so far #msmm 👇👇👇
Using whole-exome and genome sequencing data, we can capture the majority of mutations in cancer. Using bioinformatic algorithms we can identify and quantify which mutational processes are involved and responsible for this catalog of mutations (i.e. mutational signatures) 
In 2017 Weinhold and @DrGarethMorgan1 reported a new mutational signature in relapsed multiple myeloma doi.org/10.1182/blood-…. In 2018-2019 with @nickbolli we found the same signature (MM1; rdcu.be/ccTQl and rdcu.be/ccTQm), still without knowing its etiology
