Discover and read the best of Twitter Threads about #mtDNA
Most recents (4)
🎉New preprint! @LauraKremer20 and I looked at four different gene knockouts in mt.5024C>T mice to investigate how #autophagy affects #mtDNA heteroplasmy inheritance. biorxiv.org/content/10.110…
@MRC_MBU @cam_mito @mitopinionated 🧵: 1/
@MRC_MBU @cam_mito @mitopinionated 🧵: 1/
To what extent is germline purifying selection driven by autophagy? We looked at the mother-to-pup heteroplasmy shift in high-heteroplasmy mice carrying Parkin, Bcl2l13, Ulk1, and Ulk2 knockouts, as well as two separate control populations. 2/ 
While previously Filograna et al. (2019) @RobertaFilogra2 show TFAM overexpression can lead to higher maximal tolerated heteroplasmy, this was not the case for our autophagy knockouts. We saw no knockout mice with H>80%, despite having 120+ pups in each group. 3/
So excited to finally share our paper, now available as a #bioRxiv preprint!
We found that enhancing #mtDNA replication can be highly deleterious, causing #Ferroptosis and neonatal 🫀#HeartDisease. 🧵thread coming soon..
biorxiv.org/content/10.110…
#newpublication #mitochondria
We found that enhancing #mtDNA replication can be highly deleterious, causing #Ferroptosis and neonatal 🫀#HeartDisease. 🧵thread coming soon..
biorxiv.org/content/10.110…
#newpublication #mitochondria
This project would not have been possible without the fantastic work from many people, so thank you all! @ASW_lab, @Kivela_lab, @WickstromLab, @JMitophile, @AWartiovaara et twitterless al.
@HelsinkiUniMed @helsinkiuni @HelsinkiUniMed @MitoResearch @uniofjyvaskyla @UniEastFinland
@HelsinkiUniMed @helsinkiuni @HelsinkiUniMed @MitoResearch @uniofjyvaskyla @UniEastFinland
Recent years have brought several promising approaches to treat different kinds of #mitochondrial dysfunction, and increasing #mtDNA amount has been proposed to be beneficial for certain defects.
New paper in @NatureMedicine on #mtDNA variant effects on metabolites, from my colleagues and I from @sangerinstitute, @emblebi , @Cambridge_Uni and @MRC_MBU! nature.com/articles/s4159…
@nicolesoranzo @cam_mito @OliverStegle @auroradevea @joannahowson @DoingYonova
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@nicolesoranzo @cam_mito @OliverStegle @auroradevea @joannahowson @DoingYonova
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We identified common #mtDNA variants in 16K British individuals with EUR ancestry from the INTERVAL study, performed the first large-scale assoc study between #mtDNA variants and ~5000 molecular traits that directly tag metabolic processes. 2/n
We found and replicated significant associations between #mtDNA variants in Haplogroups Uk (found in 10% of the EUR population) and H3 (2%) and levels of N-formylmethionine (fMet), an amino acid known to be important for intra-mitochondrial translation. 3/n
Our article on the origin and health status of first-generation Africans from the Viceroyalty of New Spain is out now in @CurrentBiology! disq.us/t/3o8nra4 Here’s the #thread in case you can’t make the complete read:
These African individuals were first noted by @MezaAbigail and colleagues to be not Native Americans and found in a hospital which was dedicated to care exclusively for the indigenous population of the Viceroyalty of the #NewSpain
Here’s a look at the excavation site: (from: arqueologiamexicana.mx/mexico-antiguo…)
