Discover and read the best of Twitter Threads about #mthfr

Most recents (2)

1st, what a sloppy claim. The hypothesis that intracellular folate deficiency can cause symptomatic elements of #EDS is not new, but I think it's wrong. The #MTHFR polymorphism is SO common and we've gone down the MTHFR rabbit hole before. /1
You hypothesis is that decreased activation of decorin causes structural differences in collagen making it loose enough to cause hypermobility. I find it interesting that other, peer-reviewed studies say that "decorin promot[es] inflammatory activity" science.org/doi/abs/10.112… /2
suggesting that a decrease in decorin could actually be protective in disease associated with an inflammatory state, such as #EhlersDanlos. That is not to say that treating patients with the MTHFR polymorphism with methylfolate couldn't cause improvement, but /3
Read 20 tweets
#MTHFR – THE IATROGENIC GENE??
#MTHFR discovered in mid-1990's.
#MTHFR plays essential role in DNA and protein methylation-important epigenetic mechanism used by cells to control gene expression.1/
Pharmacogenomics studies the relationship between genetic variations and how our body responds to medications.2/
What happens when things go wrong?
Defective imprinting mechanisms/abnormalities in methylation can result in predisposition to diseases–cancer,muscular dystrophy,cardiovascular diseases, Alzheimer's,autism,rheumatoid arthritis,pregnancy complications,leukemia,various neoplasms.
Read 7 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!