Discover and read the best of Twitter Threads about #mutagenesis

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In silico identification of natural products from Centella asiatica as SARS-COV-2 main protease (M pro) inhibitor. 1/n

❌❌❌ #ritonavir #molnupiravir in #COVID19
No more #tryglyceride #mutagenesis

pubmed.ncbi.nlm.nih.gov/34345605/
2/n
Anti-Inflammatory and anti-vascular leakage effects by combination of Centella asiatica and Vitis vinifera L. (Grapevine) leaf extracts.
#antiinflammatory qualities #anti #vascular #leakage effect

hindawi.com/journals/ecam/…
Read 8 tweets
Ivermectin 0.2-0.4mg/kg works at the outer and inner part of cells, thru P2X, GlycineCls, has anti-inflammatory effects, proven for decades, etc.
Molnupiravir 800mg twice a day for 5 days, works thru the RdRp. Can this antiviral have the side effects similar to Remdesivir ?
Comparison studies about Molnupiravir.
Gordon et al. : the high frequencies of G-to-A and C-to-U transition mutations in coronaviruses exposed to molnupiravir.

#host DNA #mutagenesis possibility

nature.com/articles/s4159…
Kabinger et al. entertains A-to-G transitions, which can occur in coronaviruses exposed to molnupiravir, albeit at much lower frequencies.

Thus, although the biochemical evidence indicates that molnupiravir triphosphate (MTP)
is a better CTP (natural nucleotide) analog, the ..
Read 5 tweets

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