Discover and read the best of Twitter Threads about #mutations
Most recents (24)
Standard cancer detection tests are done with #tissuebiopsies.🧫
These are invasive, risky, and expensive as they require an endoscope and open surgery.
An alternative approach to this is Liquid Biopsy which is performed by drawing blood.🩸
2/n
These are invasive, risky, and expensive as they require an endoscope and open surgery.
An alternative approach to this is Liquid Biopsy which is performed by drawing blood.🩸
2/n
Liquid biopsy is an innovative solution to #cancerdetection.
▪️They use a much smaller sample and have a quicker turnaround for results compared to tissue biopsies.
▪️They are more advantageous in detecting a metastasized tumor - when cancer has spread to multiple sites.
3/n
▪️They use a much smaller sample and have a quicker turnaround for results compared to tissue biopsies.
▪️They are more advantageous in detecting a metastasized tumor - when cancer has spread to multiple sites.
3/n
🧵#Bioinformatics applied to genomics, a THREAD🧵🧵:
#Genomics is the study of the entire #genetic makeup of an #organism, including its #DNA sequence, #gene structure, and regulation of #gene #expression.
#Bioinformatics is the application of computational techniques, such as #machine #learning and data mining, to the analysis of large datasets of biological information, such as #genomic, #proteomic, and #metabolomic data.
🧵 "#Criticality: A Balance Between #Robustness and #Adaptability"
Today's SFI Seminar by @cgershen @cgg_mx:
Today's SFI Seminar by @cgershen @cgg_mx:
Regarding systems at the #EdgeOfChaos
Identifying #PhaseTransition dynamics
Citing @WagnerEvolution on #Robustness
Contrasting it with #Chaos (fragile, hard to predict, etc.)
And then #Criticality, somewhere in the middle...
Identifying #PhaseTransition dynamics
Citing @WagnerEvolution on #Robustness
Contrasting it with #Chaos (fragile, hard to predict, etc.)
And then #Criticality, somewhere in the middle...
Pfizer updated #Covid19 #boosters re BA.1 buff.ly/3QQKV2z "Preliminary results suggest #vaccines could neutralize Omicron BA.4 & BA.5" If not, BA.4/5 and other emerging #variants may again have an INFECTION ADVANTAGE in VACCINATED amid still non-sterilizing #vaccines?!
It happend before: "Rapid emergence of SARS-CoV-2 Omicron variant is associated with an infection advantage over Delta in vaccinated persons" cell.com/med/fulltext/S… #omicron #vaccination #covid19
"Early introduction and rise of the Omicron SARS-CoV-2 variant in highly vaccinated university populations" academic.oup.com/cid/advance-ar…
Sur les cas de #variole #simesque (#MPXV) détectés de par le monde, quelques réflexions d'épidémiologie, de modélisation et d'évolution de l'équipe.
Car, pour le moment, ce sont surtout les #génomes viraux qui apportent des indications !
ecdc.europa.eu/en/news-events…
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Car, pour le moment, ce sont surtout les #génomes viraux qui apportent des indications !
ecdc.europa.eu/en/news-events…
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Sans entrer dans les détails, ces infections sont causées par un (gros) #virus à #ADN.
Pour des détails cliniques et thérapeutiques, @MarcGozlan a un post très détaillé en #acceslibre 👇
lemonde.fr/blog/realitesb…
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Pour des détails cliniques et thérapeutiques, @MarcGozlan a un post très détaillé en #acceslibre 👇
lemonde.fr/blog/realitesb…
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Les épidémies de #MPXV sont beaucoup étudiées par les modélisateurs car elles ont, habituellement, un #R0<1. Autrement dit, on s'attend à ce qu'elles régressent vite.
Notre collègue @jlloydsmith les a beaucoup analysées :
journals.plos.org/ploscompbiol/a…
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Notre collègue @jlloydsmith les a beaucoup analysées :
journals.plos.org/ploscompbiol/a…
3/N
Daily Bookmarks to GAVNet 10/14/2021 greeneracresvaluenetwork.wordpress.com/2021/10/14/dai…
Book Review: Open Borders
lesswrong.com/posts/R2nQzjdu…
#BookReview #economics #immigration #SocialCommentary #politics
lesswrong.com/posts/R2nQzjdu…
#BookReview #economics #immigration #SocialCommentary #politics
Catching malaria evolution in the act
phys.org/news/2021-10-m…
#malaria #evolution #mutations #parasites
phys.org/news/2021-10-m…
#malaria #evolution #mutations #parasites
1/ When the messenger mRNA exits the nucleus, it will be loaded into a organelle called the ribosome. These little factories take the RNA blueprint and use it to build a protein.
2/ Here we introduce the concept of the Codon. The DNA is made up of 4 bases with Adenine, Guanine, Cytosine and Thymine. They have to encode 20 different amino acids. To do so, the DNA uses a codon. Its a combination of 3 nucleotides.
Daily Bookmarks to GAVNet 06/09/2021 greeneracresvaluenetwork.wordpress.com/2021/06/09/dai…
China’s Hot Summer Is Latest Test of Its Carbon-Neutrality Drive
bloomberg.com/news/articles/…
#china #ClimateChange #CarbonNeutrality #consequences
bloomberg.com/news/articles/…
#china #ClimateChange #CarbonNeutrality #consequences
Quantum Computing and Reinforcement Learning Are Joining Forces to Make Faster AI
singularityhub.com/2021/03/16/qua…
#QuantumComputing #ReinforcementLearning #ArtificialIntelligence
singularityhub.com/2021/03/16/qua…
#QuantumComputing #ReinforcementLearning #ArtificialIntelligence
Daily Bookmarks to GAVNet 05/23/2021 greeneracresvaluenetwork.wordpress.com/2021/05/23/dai…
Watch a Robot 3D Printing the Rocket for Relativity Space’s First Orbital Launch
singularityhub.com/2021/03/28/wat…
#robotics #3DPrinting #RocketProduction
singularityhub.com/2021/03/28/wat…
#robotics #3DPrinting #RocketProduction
MOBLOT: A theoretical model that describes molecular oblivious robots
techxplore.com/news/2021-05-m…
#robotics #swarms #models #oblot
techxplore.com/news/2021-05-m…
#robotics #swarms #models #oblot
Daily Bookmarks to GAVNet 05/05/2021 greeneracresvaluenetwork.wordpress.com/2021/05/05/dai…
The Virtual Lives of Children: A Screen-Time Pandemic?
morganstanley.com/articles/study…
#children #ScreenTime #RemoteLearning #consequences #research
morganstanley.com/articles/study…
#children #ScreenTime #RemoteLearning #consequences #research
Researchers are closing in on long covid
economist.com/science-and-te…
#research #COVID19 #LongHaulers #PostCovidSyndrome
economist.com/science-and-te…
#research #COVID19 #LongHaulers #PostCovidSyndrome
New insights into SARS-CoV-2 immune evasion
#SARS-CoV-2 #mutations can lead to antibody #escape. What about T cells? In our study in @SciImmunology we report how mutated epitopes evade T cell responses.
immunology.sciencemag.org/content/6/57/e… 1/7
#SARS-CoV-2 #mutations can lead to antibody #escape. What about T cells? In our study in @SciImmunology we report how mutated epitopes evade T cell responses.
immunology.sciencemag.org/content/6/57/e… 1/7
Using deep viral sequencing we identified low-frequency mutations in experimentally validated CD8 T cell epitopes of SARS-CoV-2, some of which were found as fixed mutations in global virus sequences from @GISAID. 2/7
Guided by binding predictions we selected epitopes and #mutants for further biochemical investigations by cell-free MHC-I binding assays. These analyses suggested that single amino acid changes impair binding to MHC-I molecules. 3/7
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
BCG analyzed 🔬 🇺🇸, 🇫🇷 , 🇩🇪 , 🇮🇹, 🇪🇸 Outlook
Testing's likely to follow similar trajectories
Peak COVID demand occurring in the seasonally affected first quarters of 2021 & 2022
#Novacyt #ALNOV #NCYT
bcg.com/en-in/publicat…
Testing's likely to follow similar trajectories
Peak COVID demand occurring in the seasonally affected first quarters of 2021 & 2022
#Novacyt #ALNOV #NCYT
bcg.com/en-in/publicat…
Many research papers as well as #RKI, Germany assert average start of symptoms for #COVID19 around 5th-6th day of infection and peak of infectiousness between 2 days before to 1 day after onset of symptoms.. 🧵1/. #2ndlevel #contacttracing #coronavirus
As thumbrule it takes 10-12 days for #lockdown to impact the spread of #COVID19, so duration between infection till confirmation is on avg. 10 days. This is reasonable as people would wait 1-2 days with symptoms, book a test appointment and get the results so 6+2+1+1=10 days 🧵2/
So if Person A gets infected with #COVID19 today, he will be reported as a confirmed case after 10 days. But he might have infected person B after 4 days. Person B might have infected person C after 4+4 = 8 days from today, or 2 days before person A is reported. 🧵3/
#OneYearAgo a "coronavirus #genome from a case of a respiratory disease from the #Wuhan outbreak" was published on #GenBank... 🧐#SARSCoV2
#OneYearAgo "The cluster of infections had raised fears of a potential epidemic after China said last week that the virus causing it was a previously unknown type but came from the same family of viruses that caused the #SARS and #MERS epidemics".🧐
reuters.com/article/us-hea…
reuters.com/article/us-hea…
#OneYearAgo It was suddenly clear that the virus was travelling fast... any bell ringing?🧐#covid19
cidrap.umn.edu/news-perspecti…
cidrap.umn.edu/news-perspecti…
Comment pourrait évoluer la #virulence du #SARSCoV2 pour l'homme ?
Quelques éléments de réponse dans ce #thread.
Pour des détails, il y a notre Rapport 12 du mois d'août :
covid-ete.ouvaton.org/Rapport12.html
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Quelques éléments de réponse dans ce #thread.
Pour des détails, il y a notre Rapport 12 du mois d'août :
covid-ete.ouvaton.org/Rapport12.html
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La #virulence est le mal qu’un parasite (virus, bactérie,...) fait à son hôte.
Dans le cas du #SARS-CoV-2, on peut la mesurer via le risque d’être hospitalisé ou de décéder. Sachant que cela dépend fortement de l’âge.
thelancet.com/journals/lanin…
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Dans le cas du #SARS-CoV-2, on peut la mesurer via le risque d’être hospitalisé ou de décéder. Sachant que cela dépend fortement de l’âge.
thelancet.com/journals/lanin…
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Contrairement à une idée répandue, les parasites n’évoluent pas tous pour rapidement devenir avirulents.
La #tuberculose est restée virulente.
Quand au #VIH, sa virulence semble même avoir #augmenté depuis les années 1980.
thelancet.com/journals/lanhi…
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La #tuberculose est restée virulente.
Quand au #VIH, sa virulence semble même avoir #augmenté depuis les années 1980.
thelancet.com/journals/lanhi…
3/N
#ScienceSherlock: The Mystery of New #Coronavirus Variants—What They Are, Can #Vaccines Kill Them, and More
#CoronavirusStrain
By- @kun5k
weather.com/en-IN/india/co…
(📸:The Weather Channel)
#CoronavirusStrain
By- @kun5k
weather.com/en-IN/india/co…
(📸:The Weather Channel)
Just as the world began its counterattack against #COVID19 by launching large-scale #vaccination drives,novel #coronavirus has retorted using the oldest trick in the textbook: #mutation.
#Mutantcoronavirus
#Mutantcoronavirus
The new variants,which appear to be more adept at transmitting from one person to another, have given a bout of jitters to an already anxious world.While linked to the #UK and #SouthAfrica, the origin locations of these variants and just how far they have spread, remain unclear.
Finally the second chapter of my #PhD #thesis is out 💪🥳
> 1 year after thesis submission!
Thanks so much 🙏 to my co-authors @CFlensburg @ianjmajewski and Terry Speed for their persistence and support!
(thread 👇) #RNAseq #CancerGenomics #mutations
bmcbioinformatics.biomedcentral.com/articles/10.11…
> 1 year after thesis submission!
Thanks so much 🙏 to my co-authors @CFlensburg @ianjmajewski and Terry Speed for their persistence and support!
(thread 👇) #RNAseq #CancerGenomics #mutations
bmcbioinformatics.biomedcentral.com/articles/10.11…
Our goal was to decide on the library size needed to sequence a cohort of ~90 in-house Leukaemia RNA-Seq samples to allow good sensitivity for both DE analyses and mutation calling.
We used publicly available deeply sequenced RNA-Seq samples (from Leucegene) from the same cancer type and called mutations using 6 methods (combinations of 3 popular callers and filtering methods).
We called mutations on the initial and randomly downsampled data.
We called mutations on the initial and randomly downsampled data.
Our nation-wide study on the #genomic #epidemiology of #SARS-CoV-2 #superspreader_events in #Austria is out in @ScienceTM !
doi.org/10.1126/scitra…
Please find the highlights in this thread. 1/8
doi.org/10.1126/scitra…
Please find the highlights in this thread. 1/8
Through #Phylogenetic #SARSCoV2 analyses and data integration with @GISAID @nextstrain , we unveiled the links between #Austrian clusters to the global #pandemic. Explore our data and data-driven narratives at #NextstrainAustria sarscov2-austria.org ! 2/8
#Epidemiological and #Phylogenetic data revealed the geographic origins and distributions of SARS-CoV-2 in Austria. Different viruses circulated in the ski-resort region of #Ischgl with the most dominant #Tyrol-1 linked to @nextstrain clade 20C. 3/8
À propos de #mutations du #SARSCoV2 chez les #Visons au #Danemark peu d'infos et, au minimum, une communication catastrophique. Deux threads détaillés de @firefoxx66 et @BallouxFrancois qu'on résume en français 1/10 Thread
threadreaderapp.com/thread/1324085…
threadreaderapp.com/thread/1324095…
threadreaderapp.com/thread/1324085…
threadreaderapp.com/thread/1324095…
Les visons sont, comme beaucoup de mammifères, infectés par le #SARSCoV2 avec des symptômes légers. Les élevages peuvent donc être un réservoir. Et, pour la grippe aviaire, l'homogénéité génétique des animaux d'élevage favorise les souches virulentes. 2/10
adioscorona.org/themes-questio…
adioscorona.org/themes-questio…
Il y a déjà eu des épidémies de #SARSCoV2 dans des élevages de visons aux Pays-Bas en juin qui ont conduit à des abattages massifs à cause des passages à l'homme (on a estimé que 50.000 infections ont été indirectement liées à ces élevages). 3/10
sciencemag.org/news/2020/06/c…
sciencemag.org/news/2020/06/c…
Our collaborative study unravels #SARSCoV2 #SuperSpreader events in #Austria and the inter- and intra-host mutational dynamics.
Preprint at @biorxivpreprint available now: biorxiv.org/content/10.110… !
1/7
Preprint at @biorxivpreprint available now: biorxiv.org/content/10.110… !
1/7
Through #Phylogenetic #SARSCoV2 analyses and data integration with @GISAID @nextstrain , we unveiled the links between #Austrian clusters to the global #pandemic.
Explore our data and data-driven narratives at #NextstrainAustria cemm.at/research/sars-… !
2/7
Explore our data and data-driven narratives at #NextstrainAustria cemm.at/research/sars-… !
2/7
With #Epidemiological and #Phylogenetic data we investigated the geographic origins and distributions of SARS-CoV-2 in Austria. Different viruses circulated in the ski-resort region of #Ischgl with the most dominant #Tyrol-1 linked to @nextstrain clade 20C.
3/7
3/7
Daily Bookmarks to GAVNet 7/14/2020-2
greeneracresvaluenetwork.wordpress.com/2020/07/14/dai…
Tangram Heightmapper
tangrams.github.io/heightmapper/
#maps #topological
greeneracresvaluenetwork.wordpress.com/2020/07/14/dai…
Tangram Heightmapper
tangrams.github.io/heightmapper/
#maps #topological
The Tricky Math of COVID-19 Herd Immunity | Quanta Magazine
quantamagazine.org/the-tricky-mat…
#immunity
quantamagazine.org/the-tricky-mat…
#immunity
The implications of silent transmission for the control of COVID-19 outbreaks | PNAS
pnas.org/content/early/…
#control #coronavirus #transmission
pnas.org/content/early/…
#control #coronavirus #transmission
Daily Bookmarks to GAVNet 6/15/2020-2
greeneracresvaluenetwork.wordpress.com/2020/06/15/dai…
Can asymptomatic people spread coronavirus? The confusing WHO remark, explained - Vox
vox.com/2020/6/10/2128…
#asymptomatic #spread
greeneracresvaluenetwork.wordpress.com/2020/06/15/dai…
Can asymptomatic people spread coronavirus? The confusing WHO remark, explained - Vox
vox.com/2020/6/10/2128…
#asymptomatic #spread
Mutated coronavirus shows significant boost in infectivity | Scripps Research
scripps.edu/news-and-event…
#mutations #coronavirus
scripps.edu/news-and-event…
#mutations #coronavirus
Modern monetary theory says that the state has the ability to create and maintain the value in money and most left of centre economists appear to be repulsed by that
taxresearch.org.uk/Blog/2020/06/1…
#money #MMT #value
taxresearch.org.uk/Blog/2020/06/1…
#money #MMT #value
