Discover and read the best of Twitter Threads about #myelin
Most recents (4)
Both neighborhood and family #socioeconomic status (SES) influence children’s gray matter structure & function, but what about #whitematter (WM)? What could be some mediating mechanisms? We studied these questions in 8842 children from the #ABCD Study: medrxiv.org/content/10.110…
RSI assessed microstructure in 31 WM tracts. We looked at RND, which measured *directional* intracellular water & could reflect organized #myelin, and RNI, which measured *isotropic* intercellular water & could reflect #glia/neuron cell bodies. (fig adapted Burnor et al 2021) 
Higher neighborhood disadvantage and lower parental education had independent links to lower RND (organized myelin) in forceps maj, corticospinal tract, and sup long fasciculus. These agree with previous findings of lower DTI-FA and lower WM integrity in low SES.
1/4 "Using #PEPMatch, a newly developed #bioinformatics package which predicts #peptide similarity within specific #amino #acid mismatching parameters consistent with published #MHC binding capacity,..."
nature.com/articles/s4159…
nature.com/articles/s4159…
2/4 "... we discovered that #nucleocapsid #protein shares significant overlap with 22 #multiple #sclerosis (#MS)-associated proteins, including #myelin #proteolipid #protein (#PLP).
#MultipleSclerosis
#MultipleSclerosis
3/4 "Further computational evaluation demonstrated that this #overlap may have #critical #implications for #Tcell responses in #multiple #sclerosis (#MS) patients and is likely unique to #SARSCoV2 among the major #human #coronaviruses."
All vertebrate #brains have #parvalbumin #interneurons, but in mammals they play a critical role in the function of the #cortex. @ellie_bucher‘s debut paper in Brain Structure and Function surveys the field to tell this emerging and exciting story. rdcu.be/cni5M
Parvalbumin equips these #neurons for sustained fast firing, synchronizing large areas of cortex to focus attention. Linked in vast networks which buzz with gamma #oscillations, their outputs target cell bodies and axons of principal neurons to control their interactions.
Uniquely among interneurons, #perineuronal nets and #myelin anchor and stabilise the cell bodies and axons of basket cells, tightly regulating #plasticity to bind their networks into functional structures after critical periods pass.
#Neuroscientists worldwide are increasingly studying #myelin and its amazing impact on rapid #learning, mastery, and neuroplasticity. So keep your circuits strong with deep, focused practice, but remember: #myelination requires quality versus quantity.
What Is #Myelination?
Myelination is the process of “insulating” a new neural pathway to strengthen it and to forge new default #behaviors. Heavily myelinated neural pathways are up to 300 times faster.
Myelination is the process of “insulating” a new neural pathway to strengthen it and to forge new default #behaviors. Heavily myelinated neural pathways are up to 300 times faster.
They’ve been optimized for speed and #efficiency. Increasing #myelination via intentional #practice helps us become more emotionally agile.
