Discover and read the best of Twitter Threads about #myotwitter
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We're excited to describe our research on how gene products are distributed in skeletal muscle! We began these studies with the goal of identifying distinct mRNA localization patterns in muscle, anticipating that mRNAs encoding sarcomeric genes might be locally translated
at the Z-disk. To our surprise, other mRNAs like Gapdh and Histone 1h1 were also there, and a great deal of nascent translation occurred along the sarcomere. 
The biggest surprise, however, was that mRNAs in mature skeletal myofibers are COMPLETELY dependent on microtubules to disperse throughout the cytoplasm. In cultured cells, a significant proportion of mRNA molecules undergo diffusive movement, but this type of motion essentially
A few thoughts about running a research lab in the time of COVID. Who are we? A lab of 7 scientists working on how muscle develops and regenerates. Our @NIH-funded work involves daily lab work and experiments that last weeks. To keep operating, we need to be in the lab. 1/12
After a multi-month shutdown, we returned to lab. We always wear masks and gloves and work in isolation whenever possible (different rooms, times). Between experiments, we retreat to small 1-person offices. All meetings are via Zoom (even when we are in adjacent rooms!) 2/12
Many days we eat lunch outside together separated by 6-10 ft. A risk, but talking together keeps us (me!) sane. 3/12
