Discover and read the best of Twitter Threads about #n803
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Still digesting #bladdercancer trials at #GU21. QUILT 3.032 trial clinicaltrials.gov/ct2/show/NCT03… testing #N803 in BCG-unresponsive CIS was an important result. Safety data appropriate for intravesical therapy – and CR rate was higher than seen with other drugs in similar trials.
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Note, in case you missed it (as I think most of us did) that the detailed trial results were previously reported as a press release in Dec 2020 yhoo.it/3hfCcWg (unusual for a trial under ASCO embargo?)
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N-803 (aka ALT-803) is a fusion protein: IL15 with N72D mutation (to increase affinity) fused to IL15 receptor (IL15Ra) and IgG1 Fc (improves PK and activity). The resultant IL15 superagonist activates effector NK cells and CD8+ memory T cells, without activation of Tregs.
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