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Vipin M. Vashishtha

@vipintukur

Why #Omicron VOC has predilection for upper airways? Why 🫁 are comparatively spared in Omicron infection?

1/

Recent works revealed major changes in the #Omicron biological properties (the impairment of cell surface entry & syncytia formation) compared to earlier VoCs. These major changes could be explained, at least in part, by the mutations #N764K and/or #N856K in S2 subunit.

These mutations were not previously detected in other VoCs. #N764K and #N856K generate two potential cleavage sites for SKI-1/S1P serine protease, known to cleave viral envelope glycoproteins. 3/

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Discover and read the best of Twitter Threads about #n856k

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