Discover and read the best of Twitter Threads about #nabs

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For how long protection against reinfection with #SARSCoV2 lasts after a symptomatic #Covid19 disease? Almost FIVE YEARS, according to a new modelling study 1/
papers.ssrn.com/sol3/papers.cf…
The duration of immunity in #SARSCoV2 infected people remains unclear. Recent studies have estimated that the correlate of 50% protection from re-infection was 20% of the mean convalescent #NAbs titre 2/
The sera collected from a cohort of 125 individuals with RT-PCR confirmed SARSCoV2 infections up to 386 days after symptom onset. In the subset of 65 sera collected from day 151 to 386 after symptom onset, all remained positive in PRNT50 3/
Read 10 tweets
Can #SARSCoV2 #variants fully evade #vaccine induced protection? Or even natural protection?
The rapid emergence of too many different #variants shows that the virus is struggling to survive! That is why it’s changing so fast, probably, to prolong its stay in human bodies 1/
Though #vaccines may not be working perfectly against some #VOCs, but those fully vaccinated are protected against severe disease & death. No VOC can completely evade the vaccine induced protection, especially against severe disease & death! Why?.......... 2/
The #variants do not have changes in T-cell epitopes because when you are infected with a variant that evades an antibody, that variant can go to someone else and evade their antibody too. So it spreads through the population.... 3/
Read 12 tweets
#Spike protein’ is the major target of #NAbs in infected/vaccinated people. The prefusion conformation of the Spike represents the most relevant target because Abs can successfully interfere w/ infection only if they prevent binding to target cells or prevent fusion itself 1/
Various approaches are adopted to express ‘#Spike’ protein in vivo, such as nucleic acid structures & virus vectors. Alternatively, other vaccine platforms like recombinant protein particles & inactivated vaccines can directly deliver this protein 2/
Most structural studies of the wild-type spike protein exhibited one #RBD in the 'open' conformation. By contrast, 2 or 3 RBDs were observed in the open conformation in the more infective #D614G mutant--the RBD #conformation plays a vital role in the infectivity of SARSCoV2 3/
Read 16 tweets
Developing an #mRNA vaccine is a sure-shot way to success? No! Despite the spectacular performance of #Pfizer & #Moderna vaccines, we also have a #CureVac fiasco. We need to dig in much deeper into the intricacies of developing a highly efficacious mRNA vaccine 1/
There is more than low dose & impact of VOCs behind #CureVac’s failure. And here we once again need to salute the sheer brilliance of @kkariko . Will do a little thread to explain, why! 2/
No doubt, the #CureVac used a much lower #RNA dose. Dose is lower (12 (CureVac) vs 30 (#Pfizer) vs 100 ug (#Moderna)) but no idea how that translates to protein. Need to know how much of a role the lower dose played in the lower efficacy 3/
Read 20 tweets

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