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#Thread on clinical trials of #Itolizumab - 20 patients received the drug, another 10 patients (three died) received supportive care, four doses were given, 32 patients were randomized, two patients discontinued. says Dr Sandeep Athalye @Bioconlimited
Predominantly male participation with comorbidities like diabetes, thyroid and blood pressure issues. All 20 patients who were given the drug died. In the arm which did not receive the drug, 3 patients died and 2 needed invasive ventilation before they died. #Itolizumab
Key markers for inflammation IL 6 aand TNF alpha came down in those who received the drug. Serum Ferritin levels also came down. Even D Dimer markers which indicate clotting or coagulopathy #Itolizumab
