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🧵 Based on an analogy with AAm/Sty copolymers that exhibit #UCST properties we managed to replace Sty by aromatic ring-containing CKAs (MPDL & BMDO) to obtain degradable, UCST copolymers
✅Synthesis by #RAFT
✅UCST (w/ MDO = no UCST)
✅Degradation in accelerated conditions
The UCST can be finely tuned by simply varying the amount of CKA in the copolymer. With BMDO, Tcp = 22-55°C, thus covering r.t. and the body temperature, and opening the door to biomedical applications 💊 #hyperthermia 2/9
🔴 We also found that these copolymers can be rapidly degraded under "physiological" conditions (PBS, pH 7.4, 37°C) and even in water, below or above their UCST.

How fast❓ Faster than #PLA and even #PLGA!
▶️Up to -70% decrease in Mn after 7 days! 3/9
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