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THREAD. This story in NEJM (although lacking some detail) about a German cluster of 2019-nCoV cases raises further concerns about transmission from cases both before and after symptoms and from asymptomatic or subclinical cases nejm.org/doi/full/10.10…. #nCoV #NARD 1/ 
Everyone is now familiar with the R_0 (if not, see this excellent tweetorial ). The R_0 is estimated from the current spread in a naive population and is meant to show the potential for spread. It's not an intrinsic property of the virus. 2/
The R_0 is determined by the infectiousness (mostly determined by properties of the virus itself, i.e. biology), by contact rates (sociology, demography) and by duration of infectiousness (interaction between virus and our defences). 3/
