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Reading this review on immunotherapy in glioblastoma (nature.com/articles/s4157…) @NatRevClinOncol . A few odds and ends make me wonder - is there going to be a special role for NK cells in glioblastoma? Should we be aiming to target them for more effective therapies?
Checkpoint blockade hasn’t shown much efficacy in glioblastoma, in line with relatively low mutational burden (nejm.org/doi/full/10.10…) @NEJM. Also in line with the brain as “immunoprivileged”, or at least as a place with "unusual" immune activity.
First started thinking about NK cells in GBM after reading excellent study on PDGF-DD as an activating NK cell ligand (sciencedirect.com/science/articl…) @CellCellPress - striking human data from GBM cohorts, especially with greater infiltration of NK cells than T cells into tumor.
