Discover and read the best of Twitter Threads about #neuraltube
Most recents (2)
How precise are noisy #morphogen gradients in #tissue #patterning?
It turns out that the positional information they convey to #cells in the #neuraltube is much more accurate than previously estimated!
Our new #devbio paper is out in @NatureComms: rdcu.be/cH8Fx
It turns out that the positional information they convey to #cells in the #neuraltube is much more accurate than previously estimated!
Our new #devbio paper is out in @NatureComms: rdcu.be/cH8Fx
A methodological subtlety has previously led to overestimated positional errors of the morphogen gradients in the mouse neural tube. We reanalysed the noisy gradients and found that the positional information they can convey to cells is actually orders of magnitude more precise.
Also, morphogen gradients in differently sized tissues must not be pooled and rescaled to their mean length, or else an artificial positional error is added.
We’re proud to present our #preprint, where we induce embryo-like morphogenesis in #gastruloids, resulting in the generation of trunk-like-structures (#TLS) with #somites flanking the #neuraltube @MPI_MolGen w/ @adrianobolondi . A short summary (1/12) biorxiv.org/content/10.110…
#Gastruloids are a fantastic culture system, but lack proper morphogenesis, e.g. neural cells do not form a neural tube and presomitic mesoderm does not condense into somites. Can we induce proper embryo-like morphology by mechano-chemical manipulation? Yes, we can! (2/12)
Embedding 96h #gastruloids in 5% #matrigel resulted in trunk-like-structures, with somites flanking the neural tube. Activation of WNT signaling, either alone or in combination with BMP inhibition lead to hyper-epithelialized somites arranged as a bunch of grapes (3/12)
