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#TTM2 trial showing no difference in OHCA management with hypothermia (33C) vs. Normothermia (Target 37.5C if temp reach 37.8C or higher).
- Mortality
- mRS
- QoL (EQ-5D-5L)
All no significant difference.
But hypothermia = more arrhythmia (24% vs. 16%)
nejm.org/doi/full/10.10…
- Mortality
- mRS
- QoL (EQ-5D-5L)
All no significant difference.
But hypothermia = more arrhythmia (24% vs. 16%)
nejm.org/doi/full/10.10…
Trying to figure out how to reconcile this with prior data favoring hypothermia? A few points re: TTM2:
- Only stable arrest (>20mins)
- Shockable rhythm >70%
- Average Lactate just below 6
- 54% of patient in normothermia group never had a temp >37.8C (never required cooling)
- Only stable arrest (>20mins)
- Shockable rhythm >70%
- Average Lactate just below 6
- 54% of patient in normothermia group never had a temp >37.8C (never required cooling)
Hyperion trial, which showed a benefit to TTM (33C) vs. Normothermia (37C), had sicker patients.
Even looking at enrollment time: TTM2 enrolled within 180mins in all patients, while Hyperion median enrollment 232.5 + 219mins.
nejm.org/doi/full/10.10…
Even looking at enrollment time: TTM2 enrolled within 180mins in all patients, while Hyperion median enrollment 232.5 + 219mins.
nejm.org/doi/full/10.10…
