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Death from #CMV primary infection in humans without any medical history was unexplained and the role of human inducible nitric oxide synthase (#NOS2) was unknown.
Our study reported in @NEJM today provided the first answer to both questions: nejm.org/doi/full/10.10… @ALNeehus @BigioBenedetta @BustamanteJaci1 @LaurentAbel4 @BoissonDupuis @BeziatV
It also connected 2 old friends of the lab, Davood Mansouri in Tehran (who attended a patient who died of #CMV at age 54) & Carl Nathan in NY (who discovered #NOS2 & characterized its function in mice). We found that the patient died of CMV because of AR complete NOS2 deficiency.
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