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Dementia with Lewy Bodies:

Part 2️⃣ Biomarkers
🧠💊⚕️

#Neuro #Neurotwitter #Teaching #Education

#NotEverythingIsMemory

#Dementia

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Introduction

What is a biomarker? 🏷🧪️

"A characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention." 🩸🧠

2/🧵
Introduction

What is the use of biomarkers? 🧠

Diagnostic tool🪓

Tool for staging the disease 🥼

Indicator of prognosis📡

Predic or monitor of clinical response to an intervention🚨

Remember: "tools"should aid clinicians, not be the source of all truth.

3/🧵
Read 14 tweets
Dementia with Lewy Bodies:

Part 1️⃣ Clinical features and Probable Diagnosis
🧠📚🔖

#Neuro #Neurotwitter #Teaching #Education

#NotEverythingIsMemory

#Dementia

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Introduction 🥇

DLB belongs to a family of disorders typically known as "synucleinopathies" 🔬

Other members are:

- MSA
- PD
- PDD

All of them have abnormal inclusions of α-Synuclein at a pathological level.

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⚠️⚠️⚠️
"Pathology is not pathogenesis", therefore we shouldn't assume that the presence of these pathological changes are a synonym of "protein toxicity".

Suggested reading ⬇️

jamanetwork.com/journals/jaman…

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Read 24 tweets

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