Discover and read the best of Twitter Threads about #nucleocapsid
Most recents (10)
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Wie wird #PostVac nachgewiesen?
Ein Thread fĆ¼r alle "verf*** Impffans" und #LongCovid Betroffenen, die angesichts der #PostVacFake Berichterstattung / Desinformation zu ImpfschƤden in Versuchung geraten, Geld fĆ¼r dubiose Tests auszugeben ā¬ļø
Wie wird #PostVac nachgewiesen?
Ein Thread fĆ¼r alle "verf*** Impffans" und #LongCovid Betroffenen, die angesichts der #PostVacFake Berichterstattung / Desinformation zu ImpfschƤden in Versuchung geraten, Geld fĆ¼r dubiose Tests auszugeben ā¬ļø
2ā£
Um bei #MECFS / LongCovid Symptomen einen Zusammenhang zur Impfung nachweisen zu kƶnnen, mĆ¼ssten logischerweise neben einem engen zeitlichen Zusammenhang verschiedene Sachen ausgeschlossen werden:
1. Mild verlaufene / unbemerkte Covid Infektion
2. Sonstige Vorerkrankungen...
Um bei #MECFS / LongCovid Symptomen einen Zusammenhang zur Impfung nachweisen zu kƶnnen, mĆ¼ssten logischerweise neben einem engen zeitlichen Zusammenhang verschiedene Sachen ausgeschlossen werden:
1. Mild verlaufene / unbemerkte Covid Infektion
2. Sonstige Vorerkrankungen...
3ā£
3. Sonstige virale / bakterielle Erkrankung im erweiterten Zeitraum bei Auftreten der Beschwerden
4. Psychosomatische Beschwerden oder psychische Vorerkrankungen in Zusammenhang mit Impfreaktionen und Nocebo Effekte
3. Sonstige virale / bakterielle Erkrankung im erweiterten Zeitraum bei Auftreten der Beschwerden
4. Psychosomatische Beschwerden oder psychische Vorerkrankungen in Zusammenhang mit Impfreaktionen und Nocebo Effekte
1/4 "Using #PEPMatch, a newly developed #bioinformatics package which predicts #peptide similarity within specific #amino #acid mismatching parameters consistent with published #MHC binding capacity,..."
nature.com/articles/s4159ā¦
nature.com/articles/s4159ā¦
2/4 "... we discovered that #nucleocapsid #protein shares significant overlap with 22 #multiple #sclerosis (#MS)-associated proteins, including #myelin #proteolipid #protein (#PLP).Ā
#MultipleSclerosis
#MultipleSclerosis
3/4 "Further computational evaluation demonstrated that this #overlap may have #critical #implications for #Tcell responses in #multiple #sclerosis (#MS) patients and is likely unique to #SARSCoV2 among the major #human #coronaviruses."
1/4 "Using droplet digital PCR, we found #SARSCoV2 #nucleocapsid #RNA in 7 out of 9 #adenoid and 15 out of 22 tonsil formalin-fixed, paraffin-embedded tissue blocks from post-COV individuals, despite #negative #nasopharyngeal swab #PCRs at the time of surgery..."
#pediatric
#pediatric
2/4 "... variation in memory B cell frequencies and serum-neutralizing antibody titers we observed further highlighted heterogeneity of responses that may leave some #children prone to #repeat #infection."
#pediatric #viral #persistence despite #negative #nasopharyngeal #PCR
#pediatric #viral #persistence despite #negative #nasopharyngeal #PCR
3/4 "... activated cells in these #tissues after infection may also contribute to delayed or #prolonged #sequelae of #COVID19, including long-COVID-19 and #multisystem #inflammatory syndrome in children,..."
#LongCovidKids #PASC
#LongCovidKids #PASC
The interior of a single virus particleĀ contains a dense assembly of #ribonucleoproteins (RNPs) that package the genome to form the #nucleocapsid (protein shell of a virus). Notable, it has a cylindrical shape that matches the particle geometry. 1/10
nature.com/articles/s4200ā¦
nature.com/articles/s4200ā¦
However, many peope have not understood that these viruses do not #spread exponentially, but in waves (fairy tale of #exponential #growth). 2/10
In this regard, Farr's Law should be mentioned (William #Farr on patterns of #epidemic events), which was banned from the German #wikipedia at the time, but could still be read in the English wikipedia. In the meantime it has marginally reappeared. 3/10
oxfordbrazilebm.com/index.php/coviā¦
oxfordbrazilebm.com/index.php/coviā¦
Letās shift our focus from Spike to #Nucleocapsid protein!
A new study demonstrates that genetic mutations outside the Spike are also key components in #SARS2 continued adaptation to human infection.
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A new study demonstrates that genetic mutations outside the Spike are also key components in #SARS2 continued adaptation to human infection.
1/
The #R203K-#G204R mutation is sufficient to enhance replication, fitness, & pathogenesis of #SARS2. Importantly, the R203K-G204R mutation increases #nucleocapsid phosphorylation, providing a molecular basis for these phenotypes.
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Notably, an analogous #alanine substitution mutant also increases #SARS2 fitness and phosphorylation, suggesting that infection is enhanced through ablation of the ancestral āRGā motif. A new Preprint by @TheMenacheryLab š
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biorxiv.org/content/10.110ā¦
3/
biorxiv.org/content/10.110ā¦
Yes, children mostly produced Abs aimed at #Spike protein, which the virus uses to enter cells. Adults generate similar Abs, but also develop Abs against the #Nucleocapsid protein, which is essential for viral replication 2/
pubmed.ncbi.nlm.nih.gov/33154590/
pubmed.ncbi.nlm.nih.gov/33154590/
#Nucleocapsid protein is typically released in significant quantities only when a virus is widespread in the body.
What does it mean? The kids lacked nucleocapsid-specific Abs, which suggests that they arenāt experiencing widespread infection. 3/
What does it mean? The kids lacked nucleocapsid-specific Abs, which suggests that they arenāt experiencing widespread infection. 3/
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2ā²-O methylation of its first nucleotide
Ā» doi.org/10.1038/s41467ā¦
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
Ā» doi.org/10.1038/s41467ā¦
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
Ā» doi.org/10.1101/2021.0ā¦
Japan Registry of Clinical Trials jRCTs071210011
Ā» doi.org/10.1101/2021.0ā¦
Japan Registry of Clinical Trials jRCTs071210011
The influence of #HLA genotype on the severity of #COVID19 infection
Ā» doi.org/10.1111/tan.14ā¦
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
Ā» doi.org/10.1111/tan.14ā¦
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
š5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise PolicyāThis review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-aboā¦
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
Ā» doi.org/10.1126/sciencā¦
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Ā» doi.org/10.1126/sciencā¦
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
Ā» doi.org/10.1007/s00415ā¦
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
Ā» doi.org/10.1007/s00415ā¦
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
Ā» doi.org/10.1101/2021.0ā¦
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
Ā» doi.org/10.1101/2021.0ā¦
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
š#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
Ā» doi.org/10.1016/j.jacbā¦
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
Ā» doi.org/10.1016/j.jacbā¦
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
Ā» doi.org/10.1101/2021.0ā¦
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
Ā» doi.org/10.1101/2021.0ā¦
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
ā ļø#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
Ā» doi.org/10.1148/radiolā¦
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
Ā» doi.org/10.1148/radiolā¦
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
ā ļøšNew-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
Ā» doi.org/10.1101/2021.0ā¦
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
Ā» doi.org/10.1101/2021.0ā¦
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
ā ļøšPatterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
Ā» academic.oup.com/eurheartj/advaā¦
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
Ā» academic.oup.com/eurheartj/advaā¦
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
