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Starting MICU with @HeavnerPharmD this month馃コ! Month long series of #OLWLT (1 thing WE learned today馃槉)
Posterior Reversible Encephalopathy Syndrome(PRES)鉃★笍serious馃condition characterized by
馃┖Hypertension 馃くheadache 鈿★笍seizures & 馃憖 loss
TACROLIMOUS鈻讹笍immunosuppressant
1/
Posterior Reversible Encephalopathy Syndrome(PRES)鉃★笍serious馃condition characterized by
馃┖Hypertension 馃くheadache 鈿★笍seizures & 馃憖 loss
TACROLIMOUS鈻讹笍immunosuppressant
1/
used for GVHD prophylaxis in HSCT猡达笍neurotoxicity&猡达笍HTN perpetuating the risk of PRES馃く
During an episode of GVHD鉃★笍 tac levels are often 猡达笍 to prevent worsening GVHD BUT鉃★笍猡达笍inflammation猡达笍tac馃 penetration & risk of PRES馃槦
馃洃Tac can lead to PRES even if levels are THERAPEUTIC馃洃
During an episode of GVHD鉃★笍 tac levels are often 猡达笍 to prevent worsening GVHD BUT鉃★笍猡达笍inflammation猡达笍tac馃 penetration & risk of PRES馃槦
馃洃Tac can lead to PRES even if levels are THERAPEUTIC馃洃
Management is complex鈿狅笍
馃幆 is to balance risk of GVHD Vd worsening PRES
鉁卻eizures鉃★笍benzos
鉁匟TN鈻讹笍rapidly titratable anti-hypertensives
May PRES-ur luck by馃攧 to cyclosporine鉃★笍but risk for PRES still exists馃槵
Sirolimous/MMF鉃★笍鈫橈笍risk of PRES, but efficacy 4锔忊儯 GVHD is questionable馃
馃幆 is to balance risk of GVHD Vd worsening PRES
鉁卻eizures鉃★笍benzos
鉁匟TN鈻讹笍rapidly titratable anti-hypertensives
May PRES-ur luck by馃攧 to cyclosporine鉃★笍but risk for PRES still exists馃槵
Sirolimous/MMF鉃★笍鈫橈笍risk of PRES, but efficacy 4锔忊儯 GVHD is questionable馃
