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1/In this RCT, continuous IV hydrocortisone significantly lowered the risk of death in patients with severe CAP compared to placebo. Welcome to our weekly #OMTweetorial. #MedTwitter #MedEd #EBM #JournalClub 
2/In this pre-COVID government-funded trial in @NEJM, Pierre-François Dequin et al assessed whether a continuous hydrocortisone infusion reduced mortality in patients with severe CAP.
3/Design: RCT of 800 adults admitted to ICUs in France with severe CAP. Randomized 1:1 to placebo or a 4-d continuous infusion of hydrocortisone 200 mg IV daily followed by an 8–14 d taper. All pts received abx and standard supportive care. Primary outcome: death by day 28.
