Discover and read the best of Twitter Threads about #oncogenesis
Most recents (2)
1/ Cool! But a growing # of studies show tumors arn't sterile and harbor communities of bacterial, viral + fungal organisms. Many are intracellular pathogens who’s proteins/metabolites can modulate tumor gene expression and/or viruses that directly integrate into the tumor genome
2/ This team analyzed the PCAWG Consortium datasets and found viruses in 382 genome/68 transcriptome datasets. They noted high prevalence of EBV, HPVs, AAVs, + high levels endogenous retrovirus expression linked to worse survival in kidney cancer patients: biorxiv.org/content/10.110… 
3/ Then consider studies like this, which identified a distinct + abundant pancreatic bacterial microbiome associated w/ progressive pancreatic cancer. In mice, this microbiome drove oncogenesis by suppressing macrophage differentiation + T cell activity: cancerdiscovery.aacrjournals.org/content/early/…
So we are living in an epidemic of chronic #disease..during which the collective activity of organisms in human tissue + blood is rapidly being shown to DRIVE #cancers, #Alzheimer’s etc...and this team wants us to backtrack + conform to 18th century Koch’s postulates!? C’mon! 😡
1/1 An example 👉 This team identified a distinct and abundant pancreatic #microbiome associated with progressive pancreatic #cancer. A series of experiments in mice showed this microbiome drove oncogenesis (cancer) by suppressing macrophage differentiation and T cell activity...
2/2...”In addition, targeting this cancer-promoting microbiome with antibiotics protected against #oncogenesis, reversed intratumoral immune tolerance, and enabled efficacy for checkpoint-based #immunotherapy”....: cancerdiscovery.aacrjournals.org/content/early/…
