Discover and read the best of Twitter Threads about #oncogenic
Most recents (1)
Besides #immunotherapy, how can #CRISPR be used to treat cancer?
Researchers at @CNIOStopCancer just published an exciting proof-of-concept showing how CRISPR can delete cancer-causing gene fusions, selectively killing cancer cells.
I'll elaborate.
nature.com/articles/s4146…
Researchers at @CNIOStopCancer just published an exciting proof-of-concept showing how CRISPR can delete cancer-causing gene fusions, selectively killing cancer cells.
I'll elaborate.
nature.com/articles/s4146…
First, let's discuss what gene fusions are. As shown below, fusions result when two genes crash into each other and fuse together.
The resulting protein product is a hybrid. It has some features of Protein A and some of Protein B.
This usually is very bad.
The resulting protein product is a hybrid. It has some features of Protein A and some of Protein B.
This usually is very bad.
We know that cancer-causing (#oncogenic) fusions have been found in nearly all cancer types. They're more common in pediatric cancers, but still are present in as many as 15-20% of adult cancers.
If present, fusions often are the main drivers of tumor growth.
If present, fusions often are the main drivers of tumor growth.
