Discover and read the best of Twitter Threads about #oslerpride
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đź“Ł#Preprint #COVID19 #ConvalescentPlasma
đź“ŚRCT (N=1.2K)
đź“ŚOutpatients age 18+
đź“ŚHigh-titer CCP (>1:320) vs placebo plasma w/in 9d of symptoms
đź“ŚPrimary endpt: Hosp/death by d28
📌CCP 🏆: 54% ⬇️, driven by non-ICU hospitalizations (NNT=29); HR 0.46, p<.01
medrxiv.org/content/10.110…
đź“ŚRCT (N=1.2K)
đź“ŚOutpatients age 18+
đź“ŚHigh-titer CCP (>1:320) vs placebo plasma w/in 9d of symptoms
đź“ŚPrimary endpt: Hosp/death by d28
📌CCP 🏆: 54% ⬇️, driven by non-ICU hospitalizations (NNT=29); HR 0.46, p<.01
medrxiv.org/content/10.110…
2/ A few important points about this #COVID19 #convalescentplasma trial
đź“ŚHigh-titer CCP was much higher than that used in some other studies (median titer of >1:14,580 & 95% had >1:4820)
đź“ŚMedian days to plasma: 6d
đź“Ś53 of 54 hospitalizations were in unvaxxed (#GetVaccinated!)
đź“ŚHigh-titer CCP was much higher than that used in some other studies (median titer of >1:14,580 & 95% had >1:4820)
đź“ŚMedian days to plasma: 6d
đź“Ś53 of 54 hospitalizations were in unvaxxed (#GetVaccinated!)
3/ đź“Ś Only 3 deaths in post-hosp period, all in controls
đź“Ś Few #COVID19nCancer or #immunocompromised
đź“Ś Study used #convalescent plasma mostly from Apr-Dec 2020 (ie pre-#vaccine availability)
đź“ŚWould *predict* CCP from #vaccinated to perform well vs #Omicron & #covidvariants
đź“Ś Few #COVID19nCancer or #immunocompromised
đź“Ś Study used #convalescent plasma mostly from Apr-Dec 2020 (ie pre-#vaccine availability)
đź“ŚWould *predict* CCP from #vaccinated to perform well vs #Omicron & #covidvariants
