Discover and read the best of Twitter Threads about #ovariancancer
Most recents (11)
1/8
May 8th = World Ovarian Cancer Day 2022 #WOCD2022
A thread 🧵 on some points I wish to relay as a Medical Oncologist with subspecialty in GYN oncology and based in fair Ireland 🇮🇪
May 8th = World Ovarian Cancer Day 2022 #WOCD2022
A thread 🧵 on some points I wish to relay as a Medical Oncologist with subspecialty in GYN oncology and based in fair Ireland 🇮🇪
2/8
The most common symptoms of ovarian cancer are the #BEAT symptoms - always get checked out by your GP if you have these or other symptoms that are not resolving
#knowyourbody
The most common symptoms of ovarian cancer are the #BEAT symptoms - always get checked out by your GP if you have these or other symptoms that are not resolving
#knowyourbody
3/8
There is no reliable #screening test for ovarian cancer
❌ Pap smears do not diagnose ovarian cancer
❌ Ca125 is not a reliable test
❌ Pelvic/vaginal USS may miss a diagnosis or overdiagnose a normal cyst
Until we have better screening, symptoms are all we have #BEAT
There is no reliable #screening test for ovarian cancer
❌ Pap smears do not diagnose ovarian cancer
❌ Ca125 is not a reliable test
❌ Pelvic/vaginal USS may miss a diagnosis or overdiagnose a normal cyst
Until we have better screening, symptoms are all we have #BEAT
SUBJECT: GENEROSITY, EMPATHY, AND NEED PLEASE READ
I'll apologize before hand for the length of this, but I think I need to explain everything to get the help I need.
In February 2020, I was diagnosed with stage IV ovarian cancer. I have fought to stay alive over the last 1/
I'll apologize before hand for the length of this, but I think I need to explain everything to get the help I need.
In February 2020, I was diagnosed with stage IV ovarian cancer. I have fought to stay alive over the last 1/
2/
couple yrs. I have been through multiple rounds of chemo, biologics therapy, two surgeries(1 that nearly ended my life), ect. I have went through scans every couple months, blood test and every few weeks. Though I have insurance, it rarely covers all costs. I have been
couple yrs. I have been through multiple rounds of chemo, biologics therapy, two surgeries(1 that nearly ended my life), ect. I have went through scans every couple months, blood test and every few weeks. Though I have insurance, it rarely covers all costs. I have been
3/
buried in bills. Bills that make living hard. So hard in fact that I had to move back into my parents home. At 43 yrs old, it has been no picnic. But we are all making it work.
My parents have helped me with my bills to the point where they are not in a great place
buried in bills. Bills that make living hard. So hard in fact that I had to move back into my parents home. At 43 yrs old, it has been no picnic. But we are all making it work.
My parents have helped me with my bills to the point where they are not in a great place
How do metastatic #ovariancancer tumors change during #chemotherapy to survive, eventually killing the patient? See our longitudinal #scRNAseq analysis, now out @ScienceAdvances, with accessible data & tools.
science.org/doi/10.1126/sc…
A 🧵 below (1/9)
science.org/doi/10.1126/sc…
A 🧵 below (1/9)
We collected a unique set of paired, metastatic tumor specimens from 11 high-grade serous patients treated in @TyksVsshp (by @mijohy & colleagues) before and after neo-adjuvant chemotherapy, and analysed dissociated tumors with scRNA-seq. (2/9)
Unlike stroma or immune cells, cancer cells had distinctly patient-specific profiles. To find the hidden, shared states from these genetically heterogeneous tumor specimens, @KaiyangZhang @HautaniemiLab developed a new clustering method, PRIMUS (3/9)
Hello and welcome to September journal club! I’m Kathleen, PGY2 OBGYN resident at St. Luke’s in PA, and I’ll be your host for @AAGLJMIG journal club today. We’ll be discussing salpingectomy alone approach for risk reduction of ovarian cancer (see last tweet for link) #jmigjc
Throughout today and tomorrow, I’ll be posting about the article and responding to you in between cases and clinic. Hoping we can get some great discussion going! I’ll start with background this morning and return in the afternoon #jmigjc
As we all know, risk reducing salpingo-oophorectomy (RRSO) is recommended as the standard of case for patients with genetic dispositions to #OvarianCancer. The fallopian tube is now well established as site of origin for most ovarian cancers. #jmigjc
Now that I have 100K followers, I want to talk about #OvarianCancer. Specifically my gritty story. The goal is awareness. I hope you find this narrative informative.
In January 2020 I started feeling unwell. I was tired, had vague abdominal pain, severe lower back pain & a mild increase in frequency to urinate.
I was treated with antibiotics for a UTI even though I did not have classic UTI symptoms (high bacterial load, burning pee, big increase in urge to pee).
Today is #WorldOvarianCancerDay. I am sharing my story to raise awareness about this disease. I do it with a grimace. This wasn’t supposed to be my story.
From Jan - May 2021, I had symptoms. Bloating, lower back pain, slight increase in need to urinate, fatigue. I was misdiagnosed, despite having had 2 transvaginal ultrasounds.
I was 42. They thought endometriosis. No one thought #OvarianCancer. My Uncle, an #obygyn, suggested I get a blood test to rule out cancer. My CA 125 level was 925 (normal <35). That same day I contacted a gyn/onc.
J&J dumps millions #vaccines due to poor quality of production | 01.04.21
- would dump a large volume of jabs due to registered poor manufacturing quality caused by personnel with no adequate training
europost.eu/en/a/view/j-j-…
- would dump a large volume of jabs due to registered poor manufacturing quality caused by personnel with no adequate training
europost.eu/en/a/view/j-j-…
#johnsonandjohnson halts #vaccine shipments in the US after about 15 million doses ruined by a factory mixup | Mar 31
- The plant is run by Emergent BioSolutions, a manufacturing partner to both Johnson & Johnson and #AstraZeneca
chicagotribune.com/coronavirus/va…
- The plant is run by Emergent BioSolutions, a manufacturing partner to both Johnson & Johnson and #AstraZeneca
chicagotribune.com/coronavirus/va…
The company at the heart of the J & J vaccine issue has a series of citations | 2h ago
- #EmergentBioSolutons, at the heart of the vaccine supply chain, was key to Johnson & Johnson’s plan to deliver 100M doses of #vaccine to the US by the end of May
floridanewstimes.com/the-company-at…
- #EmergentBioSolutons, at the heart of the vaccine supply chain, was key to Johnson & Johnson’s plan to deliver 100M doses of #vaccine to the US by the end of May
floridanewstimes.com/the-company-at…
@IWS_Network @universitelaval @unil @UBC Thank you @IWS_Network for allowing me to share my story here. My name is Razan Sheta, of Palestinian/Jordanian origins. Born and raised in Riyadh Saudi Arabia. I have traveled the world, and I am really looking forward to sharing my story. #IWSvoices @IWS_Network.
@IWS_Network @universitelaval @unil @UBC I left home at a young age, and was super excited to start a new adventure in Canada @UBC . At that time, I thought this is going to be my biggest adventure. Little did I know it was just the beginning. #IWSvoices @IWS_Network.
@IWS_Network @universitelaval @unil @UBC My first experience in a lab was with the late world-renowned researcher, Dr. El-Husseini's. It was an overwhelming experience. But I owe everything to the back-then PhD student who took me under her wings
@marie France Lisé. #IWSvoices
@IWS_Network
@marie France Lisé. #IWSvoices
@IWS_Network
After years of working tirelessly with our incredible campaigners, together we're celebrating a HUGE win:
@NHSEngland is launching the first-ever nationwide awareness campaign which includes #OvarianCancer symptoms 🙌💜
bit.ly/3kbAogE
@NHSEngland is launching the first-ever nationwide awareness campaign which includes #OvarianCancer symptoms 🙌💜
bit.ly/3kbAogE
We’ve campaigned for this ever since we were founded and we couldn’t have achieved this without the support of all of you!
From our ground-breaking Pathfinder research to over 14,000 of you who signed our call to action – we did it! 🎉
From our ground-breaking Pathfinder research to over 14,000 of you who signed our call to action – we did it! 🎉
Awareness of ovarian cancer symptoms is shockingly low. This campaign means more women than ever before will be aware of the symptoms, a crucial step to being diagnosed at the earliest possible stage.
Truly grateful to announce I have been promoted to Associate Professor at @MonashBiol 😊
I would like to thank my team & former team members, my collaborators, mentors, colleagues for the support and feedback @BBM_Wong and @RobertB_R, & my boss @OBryanMoira for the push to apply
I would like to thank my team & former team members, my collaborators, mentors, colleagues for the support and feedback @BBM_Wong and @RobertB_R, & my boss @OBryanMoira for the push to apply
Inspired by @jane_bourke_phd I would like to share how I got here because I look up to many & constantly think I am not doing 'well' enough. What I learned over the years is that on paper things look much more glamorous than they are (I call it the Instagram of academia) 1/
I came from a developing country (#Brazil) where research is not valued and there is little $ available. But I had amazing lecturers and teachers, and amazing opportunities to do research since I was an undergrad. This resulted in 5 papers prior to my PhD & helped me a lot 2/
Our new paper is on biorxiv! "Predicting master transcription factors from pan-cancer expression data" biorxiv.org/content/10.110…. We set out to find master TFs in ovarian cancer, and went on quite a journey... A few highlights in the thread 1/
Prioritizing candidate MTFs without ChIP-seq data is tough, so we developed a gene expression-based approach which we loving called the Cancer Core Transcription factor Specificity (CaCTS) algorithm 🌵. (We then decorated the lab in cactuses) /2
Using CaCTS we identified candidate MTFs for 34 major tumor types and 140 molecular/histologic subtypes.
Candidate MTFs tend to be associated with super-enhancers, and many are lineage-specific essential genes - woo CaCTS works! 3/
Candidate MTFs tend to be associated with super-enhancers, and many are lineage-specific essential genes - woo CaCTS works! 3/
