Discover and read the best of Twitter Threads about #pancsm

Most recents (6)

In May 2019, Dr. @rschilsky & I co-chaired the #AAADV19 Workshop Plenary Session "Decentralized #ClinicalTrials: The Future is Now." An incredible group of panelists from academia, industry, govt, & patient #advocacy 👇discussed the rationale, challenges, & opportunities of DCTs. Image
No one knew yet that the #COVID19 #pandemic was just around the corner. In Mar 2020, FDA released a guidance on conduct of #clinicaltrials during the pandemic:…, & colleagues wrote about the impact on #OncTwitter trials:…. /2
FDA has now released a draft guidance on decentralized #clinicaltrials for drugs, biological products, & devices covering #telehealth, remote assessments, consent, shipping of IP, & more:…. #MedTwitter #regulatory #drugdevelopment Image
Read 5 tweets
1/12 #TumorBoardTuesday
Thurs 10/12/21 Case🎀
@ShaalanBeg @CancerCommons present a case of #PancreaticCancer that challenges us to🤔about cell signaling & mol bio➡️better outcomes.

📚We captured as much of the chat as we could:…
#PanCan #KRAS #OncTwitter
2/12 #TumorBoardTuesday
Thurs Case🎀

We discussed #PancreaticCancer & specific #KRAS mut
✅All KRAS muts aren’t ≠
✅KRAS G12R➡️⬆️autophagy
✅Autophagy= tumor can♻️cell components ➡️resistance
✅MEKi + autophagy inhib= strat for G12R
✅Repeat NGS on prog is🗝️!
Thursday Case🎀

👉👉 Don’t forget to pick up 🆓 #CME credit by answering 3 quick ❓
Here is the post-test 🔗:

Read 15 tweets
Here it is: #LateBreakingAbstract at #ASTRO20 SS19 available to view now! Early analysis of trial (NCT03340974) using high-dose SBRT with avasopasem (GC4419) in #PancreaticCancer #PancSM #ASTRO20 Thread👇
This trial tried to address an unmet need for a specific group of #PancreaticCancer #PancSM patients whose disease had not progressed but remained unresectable after chemotherapy. #ASTRO20 @ACKoongMDPhD
Patients would be enrolled on the trial after finishing a minimum of 3 months of standard-of-care chemotherapy. They would receive SBRT with Avasopasem or a placebo control just prior to each SBRT treatment. #ASTRO20
Read 14 tweets
One day late, but wanted to summarize #PancreaticCancer #PancSM talks from yesterday’s #ASTRO20 session on hypofractionation in GI Cancers before spill the beans on my study... 1/9
@MikeChoungMD gave a great talk on the @UMiami experience with #MRLinac for #PancreaticCancer #PancSM. This is a great technology that allows #RadOnc to replan the treatment each day based on the anatomy of the nearby bowel. #ASTRO20 2/9
In this study on #MRLinac, they showed that they can safely deliver ablative doses (about 50Gy/5 fractions) with less than 2% acute and late GI tox. #ASTRO20 3/9
Read 9 tweets
Bird’s-eye view 👁 on what to look out for @WCGIC #WorldGI2020.
Opening remarks on important data 📺 @myESMO - by Dr. Eric Van Cutsem @UZLeuven.
🟩Good to see more #PrecisionMedicine🧬
🟥#Immunotherapy #Immuno-#oncology
🟦TNT & other chemo strategies
@Annals_Oncology #OncoAlert
🆕#ctDNA #liquidbiopsies 🩸🧬
👀 👇🏾at the number of #clinicaltrials cropping up in this space‼️
We have 2🇺🇸studies open. #CRCSM #WorldGI2020
#WORLDGI2020 This is 🆒 ☢️ 32-P EUS-guided implantation in #pancreascancer #PANCSM @myESMO @WCGIC @Annals_Oncology.

Still miles to go. OS median of 16 months pointing again to the systemic nature of disease. Need to piggyback these local approaches to better systemic. #OncoAlert
Read 55 tweets
Eponyms are falling out of favor in medicine. They aren't descriptive and essentially require twice the memory space to recall both the name & the associated term.

But pancreaticoduodenectomy doesn't exactly roll off the tongue so I suspect the Whipple is here to stay.
Dr. Allen Whipple was a pioneering surgeon whose contributions to the field also include a still-relevant understanding of insulinomas (see also: Whipple's triad).

Still his incisive approach to the pancreas, small intestine, and bile ducts remains why he is best-remembered
I have no operative skills myself so I like to describe that the Whipple-performing surgeon does to the upper abdomen what Picasso did to faces: radical rearrangements that, in the end, bare some vague semblance to the original orientation of features.
Read 10 tweets

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