Discover and read the best of Twitter Threads about #pcsm

Most recents (3)

1/
TWEETORIAL of GETUG-16 and hormone therapy with SRT

I have been asked many times to discuss this paper and my views on the topic now that the GETUG-16 was updated. It is a great trial with numerous strengths. So here we go…
@MCWardMD @RTendulkarMD @subatomicdoc #PCSM
@MCWardMD @RTendulkarMD @subatomicdoc 2/
Overall the trial can be viewed as positive or negative. How is this?

Original primary endpoint: PFS = was met!

Sample size was increased to be powered for OS, which was not met. So the endpoint the trial was actually powered for was not met = negative.
@MCWardMD @RTendulkarMD @subatomicdoc 3/
PFS should really not be used for ph3 trials. PFS basically equals BCR, which will near always be improved w/ ADT as you are inhibiting the PSA-based endpoint you are measuring. Even in RTOG 9408 low risk pts have a BCR benefit. Signal finding not practice changing.
Read 15 tweets
So @ANZUPtrials #ENZAMEt #PCSM results fro #HRQOL were presented today at #ESMO19, here are some of the headline outcomes 1/5 #InternationalCollaboration #RCT
@ANZUPtrials Acknowledgements usually come last but we can't do these studies without #patients. So our very sincere thanks to the 1125 men living with mHRPC #PCSM who volunteered to take part, have the treatment, & fill out #HRQOL questionnaires! #ENZAMET @anzupartners #ESMO19 2/5
@ANZUPtrials @anzupartners In the @ANZUPTrials #ENZAMET study we measured #HRQOL using @EORTC_QLG's #QLQC30 (global qol, social, physical, emotional, functional domains) & Prostate Cancer module #PR25 at weeks 0, 4, 12, then 12-weekly until clinical progression #PCSM #ESMO19 3/5
Read 7 tweets
Radiation to the prostate for metastatic prostate cancer is now endorsed by NCCN 2019. This topic can be a bit confusing, so here is a tweetorial for residents & community practice #radonc docs (including my #CleClinicCancer colleagues taking oral boards soon). #pcsm 1/21
I recently pieced together some key points on primary prostate RT for M1 for a resident teaching session, which I thought I’d share here. Apologies in advance if any typos or errors in this thread. 2/21
First, some definitions. mCSPC = metastatic castrate sensitive prostate ca. MDT = metastasis directed therapy (surgery or SBRT to all sites). Oligomets = 1-3 or 1-5 mets. 3/21
Read 23 tweets

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