Discover and read the best of Twitter Threads about #pdac
Most recents (5)
1. ENTER #mRNAvaccines for #pancreaticcancer! Long-term #PDAC survivor story PART3.
"Do #PDACs REALLY have vaccine neoantigens (NAs)"? (aren’t they lowly mutated?)
If each patient = own NAs, how do you vaccinate?
Maybe mRNA? But how?
@Nature nature.com/articles/s4158…
👇🏽 [1/32]
"Do #PDACs REALLY have vaccine neoantigens (NAs)"? (aren’t they lowly mutated?)
If each patient = own NAs, how do you vaccinate?
Maybe mRNA? But how?
@Nature nature.com/articles/s4158…
👇🏽 [1/32]
2. In 2017, we reported in @Nature here -> nature.com/articles/natur… -> that primary tumors of long-term survivors of #PDAC had ~12x more activated CD8 T cells vs. short-term survivors
AND
despite #PDAC’s few mutations, mutation-derived NAs may still be T cell antigens in #PDAC.
AND
despite #PDAC’s few mutations, mutation-derived NAs may still be T cell antigens in #PDAC.
3. Now, prevailing belief ->#PDAC = few mutations = fewer mutation-derived NAs = NAs unlikely #PDAC T cell antigens.
BUT...our #NeoantigenQualityModel(estimates the ~1-2% of immunogenic NAs)
found that long term #PDACsurvivors ∝ more “high quality” NAs ∝longer survival.
BUT...our #NeoantigenQualityModel(estimates the ~1-2% of immunogenic NAs)
found that long term #PDACsurvivors ∝ more “high quality” NAs ∝longer survival.
Today, in @Nature, we reveal PART 2 of our investigations on
“What IS going on in long-term survivors of #PancreaticCancer (#PDAC)?”
“Is it REALLY the immune system?”
Well…more evidence here - > nature.com/articles/s4158…
Thread below [1/30]
“What IS going on in long-term survivors of #PancreaticCancer (#PDAC)?”
“Is it REALLY the immune system?”
Well…more evidence here - > nature.com/articles/s4158…
Thread below [1/30]
In 2017, we reported in @Nature here -> nature.com/articles/natur… -> that primary tumors of long-term survivors of #PDAC had ~12x more activated CD8 T cells vs. short-term survivors. Now, others had reported this before - but we wanted to know:
“What are the antigens?”
“What are the antigens?”
Really chuffed to share our latest work from Sanjana Lab out in @nature today (nature.com/articles/s4158…).
We tested >12,000 genes to find positive regulators of T cell proliferation to be used for next-gen #immunotherapies.
A thread...
We tested >12,000 genes to find positive regulators of T cell proliferation to be used for next-gen #immunotherapies.
A thread...
(2/28) T cell therapies have shown the potential to cure patients from #cancer – but even in B cell cancers, relapses outnumber cures… One of the problems is limited T cell persistence. #celltherapy #CARTcell
(3/28) We wanted to find new genes (including genes never expressed in T cells) that could improve T cell persistence. Now, the question was: should we use #crispr activation or directly deliver target genes on a #lentivirus?
1/8 #TumorBoardTuesday
➡️This week's Thurs Case🎀 is here!
🔬We discussed locally advanced #PancreaticCancer--& sig of germline muts (ATM). @SirohiBhawna takes us on her pt’s treatment journey.
🗝️insights 🤔on locally advanced #PANCAN below!
#PancreaticCancerAwarenessMonth
➡️This week's Thurs Case🎀 is here!
🔬We discussed locally advanced #PancreaticCancer--& sig of germline muts (ATM). @SirohiBhawna takes us on her pt’s treatment journey.
🗝️insights 🤔on locally advanced #PANCAN below!
#PancreaticCancerAwarenessMonth
1.5/8 #TumorBoardTuesday
👉👉 Don’t forget to pick up your 🆓 #CME credit by answering 2 quick❓
Here’s the post-test 🔗: bit.ly/3ws480C
ALL CME 🔗: integrityce.com/tbt Now...on to the case!
👉👉 Don’t forget to pick up your 🆓 #CME credit by answering 2 quick❓
Here’s the post-test 🔗: bit.ly/3ws480C
ALL CME 🔗: integrityce.com/tbt Now...on to the case!
2/8 #TumorBoardTuesday
Thurs Case🎀
11/09/2021
Take🏠:
✅Upfront tx depends on pt- mFFX vs gem/nab-pac
✅Test all #PDAC for germline mut regardless of FH!‼️
✅Screen w annual MRI/EUS in gATM
✅Emerging 💊combos tx ATM-mut
✅#PANCAN req multi-D- role for palliative SBRT, ?IRE
Thurs Case🎀
11/09/2021
Take🏠:
✅Upfront tx depends on pt- mFFX vs gem/nab-pac
✅Test all #PDAC for germline mut regardless of FH!‼️
✅Screen w annual MRI/EUS in gATM
✅Emerging 💊combos tx ATM-mut
✅#PANCAN req multi-D- role for palliative SBRT, ?IRE
#TumorBoardTuesday
💥Wow - this week was TOO much‼️
A🗣️on TMB-high #PancreaticCancer & #Immunotherapy by @DrBonillaOnc
AND our 1st pt-directed🗣️led by @HPolymenis and @StephenVLiu
👉Don’t forget your🆓#CME credit-answer 3 quick❓
Here's the postest🔗
surveymonkey.com/r/6JVHCSG
💥Wow - this week was TOO much‼️
A🗣️on TMB-high #PancreaticCancer & #Immunotherapy by @DrBonillaOnc
AND our 1st pt-directed🗣️led by @HPolymenis and @StephenVLiu
👉Don’t forget your🆓#CME credit-answer 3 quick❓
Here's the postest🔗
surveymonkey.com/r/6JVHCSG
#TumorBoardTuesday
Thursday Case🎀
(Case from 06/01 and 06/02/21)
We discussed #PancreaticCancer and:
✅Cynicism/Nihilism
✅The importance of multi-D care
✅1st line Tx
✅🧬Testing
✅#Immunotherapy
We captured as much as we could in this moment:
twitter.com/i/events/13999…
Thursday Case🎀
(Case from 06/01 and 06/02/21)
We discussed #PancreaticCancer and:
✅Cynicism/Nihilism
✅The importance of multi-D care
✅1st line Tx
✅🧬Testing
✅#Immunotherapy
We captured as much as we could in this moment:
twitter.com/i/events/13999…
#TumorBoardTuesday
Thursday Case🎀
(Case from 06/01 and 06/02/21)
And also this moment:
twitter.com/i/events/14005…
Thursday Case🎀
(Case from 06/01 and 06/02/21)
And also this moment:
twitter.com/i/events/14005…
