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📰Out NOW in @CancerCell ‼️👉cell.com/cancer-cell/fu… 🎉What underpins anti-PD-1 response in ccRCC?
Results from ADAPTeR Phase II clinical trial, bulk/single-cell analysis of longitudinal tumour samples ⤵️(1/15) @royalmarsdenNHS @TheCrick @uclcancer
Results from ADAPTeR Phase II clinical trial, bulk/single-cell analysis of longitudinal tumour samples ⤵️(1/15) @royalmarsdenNHS @TheCrick @uclcancer
Intratumour heterogeneity (ITH) is pervasive in ccRCC & longitudinal data on anti-PD1 response is scarce 🚨 Thus we performed multi-omics analysis on 115 multiregion tumour samples, taken at baseline, week-9, & PD, from 15 treatment-naïve patients treated with nivo 🔬 (2/15)
What are the determinants of anti-PD1 response? 🤔 In keeping with other studies, no nsSNV/fsINDEL/copy number event, nor TMB/wGII (measure of chromosomal complexity) correlated with response, pre or post-nivo, even accounting for ITH (3/15)
