Discover and read the best of Twitter Threads about #pegylated

Most recents (2)

@IPiikki @turnusband "PEG-nanokantajat pääsevät kulkemaan elimistön biologisten esteiden läpi. Ne menevät rasvaliukoisina nanokantajina myös [1]veri-aivoesteen läpi ja jos ne läpäisevät veri-aivoesteen, ne läpäisevät myös istukan."
@IPiikki @turnusband #PEGylated lipids; #ALC135
ALC-135 is functional Cationic lipid of the vaxx.
-introduction of an aquenos #RNA solution.. at a specific pH leads to an #electrostatic interaction between #negatively charged RNA backbone and #positively charged Cationic lipid
@IPiikki @turnusband #SINOPEG #China Pat. #CN112220919A
Nano #coronavirus recombinant vaccine taking #GrapheneOxide as carrier
- The invention; field of nano materials and biomedicine, and relates to a vaccine, to devt of #2019nCoV #coronavirus nuclear recombinant nano vaccine
Read 24 tweets
🧵 Based on an analogy with AAm/Sty copolymers that exhibit #UCST properties we managed to replace Sty by aromatic ring-containing CKAs (MPDL & BMDO) to obtain degradable, UCST copolymers
✅Synthesis by #RAFT
✅UCST (w/ MDO = no UCST)
✅Degradation in accelerated conditions
The UCST can be finely tuned by simply varying the amount of CKA in the copolymer. With BMDO, Tcp = 22-55°C, thus covering r.t. and the body temperature, and opening the door to biomedical applications 💊 #hyperthermia 2/9
🔴 We also found that these copolymers can be rapidly degraded under "physiological" conditions (PBS, pH 7.4, 37°C) and even in water, below or above their UCST.

How fast❓ Faster than #PLA and even #PLGA!
▶️Up to -70% decrease in Mn after 7 days! 3/9
Read 10 tweets

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