Discover and read the best of Twitter Threads about #permissivehypoxemia
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#COVID19 Early vs delayed intubation. IMV has many known adverse effects and complications. Why would anyone want to intubate early? Two proposed reasons: 1) Prolonged hypoxemia might be harmful 2) Severely increased work of breathing might actually increase lung damage. (1)
1⃣Should we tolerate hypoxemia? Physiology 1st: If nothing else changes, even a 40% sat would still mean a DO2 of about 2x VO2 (normally 5x greater). Increased CO can improve this a lot. A young, previously healthy and hemodynamically stable pt should tolerate 80% just fine (2) 
In the words of Dr Martin J. Tobin: Evidence of end-organ damage is difficult to demonstrate in patients with PaO2 above 40 mmHg (equivalent to oxygen saturation of approximately 75%). doi.org/10.1164/rccm.2… (3)
