Discover and read the best of Twitter Threads about #phages
Most recents (6)
2nd day of Research Presentations at the IACFS/ME Conference iacfsme.org/2022-conferenc…: Dr. Lily Chu, Vice-President of #iacfsme welcomed attendees and presenters. #CovidIsNotOver #mecfs #LongCovid @itsbodypolitic #COVID19
Dr. Daiki Takewaki presented from Tokyo on how:“Dysbiosis in the gut microbiome accompanies skewed immunological and clinical parameters in patients with ME/CFS”. #CovidIsNotOver #mecfs #LongCovid #iacfsme #COVID19 @itsbodypolitic
The Japanese study confirms significant dysbiosis in ME patients, versus controls. #CovidIsNotOver #mecfs #LongCovid #iacfsme #COVID19 @itsbodypolitic
Interested in #phages, #metagenomics and #microbiome? New method out to bin #phages from shotgun metagenomics data by @jojohansen from our group. (1/12)
nature.com/articles/s4146…
nature.com/articles/s4146…
Discover and analyse #phages in any #Metagenomics shotgun dataset by:
1. Bin and identify high quality phage bins
2. Automatically defines viral populations across samples
3. Analysis of viral-host interactions within samples
1. Bin and identify high quality phage bins
2. Automatically defines viral populations across samples
3. Analysis of viral-host interactions within samples
Using two paired #metagenomics and #metaviromics datasets:
17-36% of HQ viruses in metavirome was found from metagenomics samples using PHAMB
46-89% of HQ viruses found by PHAMB in metagenome data was not found in the metavirome
17-36% of HQ viruses in metavirome was found from metagenomics samples using PHAMB
46-89% of HQ viruses found by PHAMB in metagenome data was not found in the metavirome
Systems defending microbes (#CRISPR, R-M, etc) from #phages and other mobile genetic elements (MGEs) are increasingly found in MGEs themselves (within cellular genomes). So, who's defending whom from what? An essay ecoevorxiv.org/zuh4c 1/5
Why are there so many defense systems in each genome? It's reasonable to think that they allow multi-layered diverse defenses from phages. But what if they are mostly the result of the multiplicity of MGEs in genomes? 2/5 
How do defense systems affect gene flow? Less transfer could be a costly by-product of defense systems. But MGEs have often more to lose than to gain from infection by other MGEs. Lowering gene flow may be a primary reason of selection for defense systems (by MGEs). 3/5
Check out our new paper by @smartinezarbas et al. about #CRISPR mediated interactions within a wastewater #microbiome in @NatureMicrobiol! Exciting collaboration between @uni_lu @TGen @IUBloomington @isbsci @KU_Leuven. Funding by @FnrLux
nature.com/articles/s4156…
A 🧵👇
1/9
nature.com/articles/s4156…
A 🧵👇
1/9
In parallel with recent work of @mhe345 @NatureComms nature.com/articles/s4146…, we explored the roles of #plasmids and #phages within a wastewater treatment plant microbial community, using longitudinal integrated #omics data 2/9
Cool history in this article 👉 But, IMO, #immunology will not “come of age” until it becomes common practice to study the human #immune response in concert w/ the genetic + metabolic activity of the body’s microbial/viral ecosystems
For example, we should study T cell #immunotherapies in concert with the activity of #tumor-associated microbiomes☝️ This study is a good example of how that trend has potential: cancerdiscovery.aacrjournals.org/content/early/…
We also now realize that billions (trillions?) of #phages persist in human tissue/blood 👉 And certain phages can modulate innate #immunity via phagocytosis and cytokine responses..+ adaptive immunity via effects on antibody production: ncbi.nlm.nih.gov/m/pubmed/30585…
This! The activity of the host #immune response largely determines whether #pathobionts acquired from an #FMT donor might become capable of virulence 👉 So including immune status in the study of FMT outcomes would be extremely informative
IMO immune status should be included in the general study of #antibiotic resistant infection 👉 It’s no coincidence that most “superbug” infections occur in immunocompromised patients, often in hospitals (w/ patients on cocktails of steroids for procedures like organ transplants)
Because extrapolate that trend and consider that the immunosuppressive biologics used to palliate “#autoimmune” disease symptoms are the top selling medications in the world 👉 With top side effects of such drugs being “serious #infection by viruses, fungi or bacteria”(see below)
