Discover and read the best of Twitter Threads about #phase1

Most recents (7)

The weather in the middle east is already pretty weird - but it is about to get a lot weirder.

Simulations show a spectacular monsoon driven burst of water and energy pulsing over the Arabian Peninsula, bringing rain to the entire desert land mass over the next three weeks.
This thread's coverage fits into our #ExtremeWeather #ClimateChangeNow #DesertRain #ArabianStorms and #WestAfricanMonsoonBurst baskets.

The animations above and below are both from this afternoon. And they show the developing weather patterns which will bring this event.
This is part of series of threads looking at a developing Sahara Water Transportation event (atmospheric river) which appears to be central component of this which was first noted here on December 5th (#AwesomeClimate) .
Read 23 tweets
SNEAK PREVIEW: Complete Path Enumeration (CPE) for CRM #dosefinding designs

Featuring a vignette for #Rstats package #precautionary update v0.2-3, currently under review by CRAN. 1/

precisionmethods.guru/DTAT/CPE/MCSE-…
This demonstrates the feasibility of a programme I’ve set forth, for the ‘exact’ simulation of ANY dose-escalation design.

Influenced by @MarkusTriska‘s exacting perspective on ’exactness’, however, I now use the more precise term ‘MCSE-free’. 2/
@MarkusTriska ‘MCSE-free’ in turn alludes to the title of recent work by Thomas M. Braun, from which I adapt my application.

(Braun’s mean-field approach truly can be called ‘simulation-free’, whereas I DO simulate the trials—just without Monte Carlo error.) 3/
Read 21 tweets
Looking forward to leading one of only two nationally awarded ‘Anti-Opioid Vaccine Development Programs’, along with @levy_o, and working with our fantastic @PrecVaccines team and collaborators from several institutions! Here is the official news: discoveries.childrenshospital.org/covid-19-opioi…
A brief thread to give an overview of our team, some background science on our anti-opioid vaccine strategy and put into perspective why I choose to work on this problem personally...
First, as outlined on our @PrecVaccines account, the goal of the award is to develop an adjuvanted #vaccine for treatment of #opioid use disorder, and bring it to a #Phase1 #ClinicalTrial right here @BostonChildrens:
Read 29 tweets
Looks like Gen Durrani has left world of current affairs and chosen to be more of philosopher than being proponent of realpolitik. Poor “assessment” as he would say. 👎🏿
At heart of this whole fiasco is IK/Bajwa in #Phase1 sitting in lap of megalomaniac MBS. Gleefully accepted all the economic benefits including MOU on key investments including $20bn oil refinery. In same period #Pulwama & #Balakot took place in which Saudi FM played crucial role
Then came real deal breaker #5August actions of Modi in J&K. Pakistan expected fierce response from OIC and kingdom but it was their own naivety. Kingdom understands geopolitical significance of India vis-à-vis IndoPacific and diversification of its own economy.
Read 5 tweets
So Toronto and the Golden Horseshoe remain in #Phase1 while this is the arrivals schedule at Pearson for today:
- New Dehli
- Addis Ababa via Dublin
- Santiago
- Seoul
- Chicago
- Detroit
- Chicago
- Lahore/Karachi
- Shanghai
- LA
- London
- Bogotá
- Charlotte
- Beijing
- London
- Frankfurt
- Amsterdam
- NY
- Dallas
- Mexico City
- Kingston
- Washington
- Chicago
- Boston
- NY
- Shanghai
- Hong Kong
- Detroit
- Charlotte
Who is coming in on these flights?

If 14d quarantine is required what urgent business do 30 planes’ worth of passengers have that couldn’t be done remotely?

3 months in, why are we still providing family member exemptions?

We can’t have a coffee on a patio but this is ok?
Read 4 tweets
Slowly digesting #ASCO20. Lots of fantastic patient-reported outcomes #PRO work incl in #phase1 #oncology.

5 presentations that caught my attention:
1/5 eRAPID (#7002) @DrKateAbsolom @UniversityLeeds.
💡RCT of weekly #PRO reporting and self-mx vs usual care for pts on chemo.
❗️ ⬆️early sx control, self-efficacy and #QOL w/o increasing clinical workload.
❓adapt for IO/ targeted therapy, monitoring during #COVID19
2/5 Creating composite PRO-CTCAE scores (#7018) @BiostatGirl @EthanBasch1
💡Developed algorithm for composite scores for PRO-CTCAE, combining frequency, severity and interference into a single metric like CTCAE.
❗️Will aid PRO-CTCAE uptake/ interpretation in trials/ routine care
Read 7 tweets
First tweet (not posted by a political handle or advertisments) in our data collection with #loksabhaelections2019! First tweet with inked status! #Elections2019 #SocialMedia #VotingRound2 #IndiaElections2019 #ProfGiri #Research #TNElection2019 #OruviralPuratchi
From 0700 - 0830, we have 20,019 tweets (original, retweets, quotes). Around 9,075 unique users posted these tweets with 2,200 users posting original tweets. Most popular hashtags: #LokSabhaElections2019 14774, #TNElection2019 6153, #Elections2019, 3165, #Ajith 2342, #Thala 2186
Most active users with their number of tweets (original, retweets, quotes) posted,
('@RanjanaSiroha', 76),
('@ThalaDhas', 70),
('@Ebinson18', 64),
('@PsYcho_bwy', 61),
('@Thala15111', 59)
Read 21 tweets

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