Discover and read the best of Twitter Threads about #phenotypes

Most recents (6)

🚨Exciting pre-print from the lab!👉"Pervasive evolution of tissue-specificity of ancestral genes differentially shaped vertebrates and insects". Deep comparative #transcriptomics across #bilateria by @FedeMantica et al @CRGenomica. 👀…. Summary👇
How has tissue-specific gene expression evolved since the origin of bilaterian animals all the way to extant vertebrates and insects? To address this, we assembled a vast RNA-seq dataset covering 8 tissues and 20 species, generating 95 new RNA-seq samples for 15 species. 1/16 Image
Importantly, our study was entirely designed around a symmetric #phylogeny for the vertebrate and insect branches, allowing us to identify ancestral features but also parallel, convergent and divergent evolutionary trajectories between and within the two bilaterian lineages. 2/16 Image
Read 19 tweets
Carolyn Calfee Clinical and Biological phenotypes of ARDS
- what do they have in common?

ARDS : subgrouping since the begining
- sepsis vs. non sepsis
- hyper vs. hypoinflamm
- reactive vs uninflamed
#ventilation #ards #phenotypes #LIVES2022
Are clinical phenotypes biologically distinct?
looking at Trauma vs. Non trauma

ICAM-1 , SP-D, vWF, sTNFr-1 are different.
What about in "Direct" vs. "indirect"
or "Diffuse" vs "focal" -- sRAGE comes up again.
#ventilation #ARDS #LIVES2022
Read 13 tweets
The Webinar on "Monoclonal gammopathy and its significance for kidneys" is about to begin!
There is still time to test your knowledge by solving the @ISNeducation quiz ➡️
Starting now!
Webinar: "Monoclonal Gammopathy of Renal Significance - Clinical Perspective" with
@arzuvelix and Serhan Tuglular
Welcome Dr @arzuvelix and Dr Serhan Tuglular
Webinar: "Monoclonal Gammopathy of Renal Significance -Clinical Perspective" with

Read 44 tweets
The promised #Tweetorial on validation of #COVIDー19 phenotypes that we published @AnnalsATS

But before we start.

- I'm a splitter and 💕 phenotypes
- If physiology can teach us; I'm all for it!
- But, data and physiology should converge

What we know:
- #ARDS can be split into #phenotypes
- But, uncertain therapeutic implications

- #COVID-19 might be split into phenotypes as well
- But, ☝️based on #physiology with little data to back it up.
- H phenotype = ⬆️elastance (=⬇️compliance) + ⬆️ lung weight + ⬆️shunt + ⬆️recruitability. What we consider ARDS.
- L phenotype is opposite - not resembling most ARDS cases.. Would not benefit ⬆️PEEP, ⬆️TV?

Lung morphology is explained here:
Read 9 tweets

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