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Our paper on #polymutant SARS-CoV-2 spikes (led by Fabian Schmidt and Yiska Weisblum with @theodora_nyc and @NussenzweigL) now published in @Nature…
It shows that plasma antibodies target numerous epitopes in SARS-CoV-2 spike such that ~TWENTY mutations are needed for neutralization escape from polyclonal antibodies elicited by infection or vaccination.
Notably, antibodies from those who had been BOTH infected AND later vaccinated (2x mRNA), neutralized the #polymutant and as well as diverse bat/pangolin sarbecoviruses and SARS-CoV
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