Discover and read the best of Twitter Threads about #preeclampsia
Most recents (12)
Did you know that pregnant people with #antiphospholipidsyndrome (APS) have an increased risk of adverse maternal & fetal outcomes? (1/4)
APS is characterized by #thrombosis and/or obstetric morbidity in the presence of #antiphospholipid antibodies. For pregnant people, this means increased likelihood of severe #preeclampsia, preterm birth, & #neonatalmortality. (2/4) 
Studies show that complement activity plays a key role in aPL-mediated #thrombosis & obstetric complications. And fortunately, complement inhibitors, like #eculizumab, offer promise of improved outcomes for pregnant people living with APS. (3/4)
Lots of discussion about lack of advancement in women's health
Here is the thing. We will NOT advance reproductive/pregnancy/women's health science by continuing to do clinical trials that are NOT based on fundamental mechanisms that drive health & disease
hang on...🧵🧵🧵
1/
Here is the thing. We will NOT advance reproductive/pregnancy/women's health science by continuing to do clinical trials that are NOT based on fundamental mechanisms that drive health & disease
hang on...🧵🧵🧵
1/
Let me explain:
Millions (millions)💲 have been spent to perform clinical trials to decrease adverse pregnancy outcomes such as #preeclampsia
Trials on Vitamin C, E, magnesium, aspirin, calcium
Perhaps, you might be thinking--those are pretty generic interventions 👀
2/
Millions (millions)💲 have been spent to perform clinical trials to decrease adverse pregnancy outcomes such as #preeclampsia
Trials on Vitamin C, E, magnesium, aspirin, calcium
Perhaps, you might be thinking--those are pretty generic interventions 👀
2/
And you would be right. They are.
Vit C & E clinical trial was based on concept that there is evidence of oxidative stress in placentas from preeclamptic individuals
OK. Yes, but oxidative stress is a pretty ubiquitous biological event
3/
Vit C & E clinical trial was based on concept that there is evidence of oxidative stress in placentas from preeclamptic individuals
OK. Yes, but oxidative stress is a pretty ubiquitous biological event
3/
We hope you enjoyed @ConwaySPHERE on @10Things_ToKnow last night on @RTEOne (catch us on here if you missed it bit.ly/2Yvt8rb )
But that's not all from us for this year's #ScienceWeekIreland ...
More details in thread (1/3) ⬇️
But that's not all from us for this year's #ScienceWeekIreland ...
More details in thread (1/3) ⬇️
Wednesday Nov 10th @ConwaySPHERE will be featured on @RTEOne "Science to the Rescue" where we'll discuss our @scienceirel funded "AI For Societal Good" winning project #AI_PREMie & our goal to save lives of🤰+👶 from #preeclampsia
More details➡️rte.ie/lifestyle/livi…
(2/3)
More details➡️rte.ie/lifestyle/livi…
(2/3)
Finally, Thurs Nov 11th for @scienceirel @DeptofFHed #CreatingOurFuture initiative we're hosting an awareness tea/coffee morning in @ucddublin to discuss thrombotic disorders & women’s health with @ThrombosisIrL& @UCDDiscovery
(3/3)
Details: bit.ly/3pYiDrL
(3/3)
Details: bit.ly/3pYiDrL
Can you monitor maternal & fetal safety in clinical trials in pregnancy? Now you can, with #MFAET version 1.0 published this week @ISPDHQ
The 12 maternal & 19 fetal Adverse Event definitions are adopted by @MedDRAMSSO
obgyn.onlinelibrary.wiley.com/doi/10.1002/pd…
ucl.ac.uk/womens-health/…
The 12 maternal & 19 fetal Adverse Event definitions are adopted by @MedDRAMSSO
obgyn.onlinelibrary.wiley.com/doi/10.1002/pd…
ucl.ac.uk/womens-health/…
1/ Researchers @ucl @UCL_IfWH @UCLHresearch have developed a standard terminology for safety monitoring for pregnant women and their fetuses during development of drugs for pregnancy. #Pregnancy #AdverseEvents #MaternalSafety #fetus #MedDRA #MFAET
ucl.ac.uk/news/2021/oct/…
ucl.ac.uk/news/2021/oct/…
2/ Adverse Event (AE) monitoring is central to assess therapeutic safety. The lack of an AE framework in pregnancy trials severely limits understanding risks in pregnant women. #MFAET was developed by international consensus of healthcare professionals & patient public groups.
New research from @JohnsHopkins about maternal health!
Vaught AJ, Minhas A, Boyer T et al. Incidence of essential hypertension but not echocardiographic abnormalities at four years with a history of preeclampsia with severe features.
#ph260720 #Moms
pubmed.ncbi.nlm.nih.gov/34182431/
Vaught AJ, Minhas A, Boyer T et al. Incidence of essential hypertension but not echocardiographic abnormalities at four years with a history of preeclampsia with severe features.
#ph260720 #Moms
pubmed.ncbi.nlm.nih.gov/34182431/
In this new study, we followed up with women four years after they were diagnosed with preeclampsia during pregnancy. What type of research study is that?
#ph260720 #Epidemiology
#ph260720 #Epidemiology
Preeclampsia is a pregnancy-specific disorder that causes high blood pressure and evidence of damage to the kidneys and/or liver. Preeclampsia and other hypertensive disorders of pregnancy impact between 5-8% of births in the US.
#ph260720 #preeclampsia
#ph260720 #preeclampsia
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.
1/17 Taking forward the theme of #WorldKidneyDay let’s discuss what it means for “#WOMEN to live well with #kidney disease” 💃
🧵ahead is for anyone who cares about 💃!
@womeninnephro #womenempowerment #WomensDay #WomensHistoryMonth
Q-Do kidney diseases affect women differently?
🧵ahead is for anyone who cares about 💃!
@womeninnephro #womenempowerment #WomensDay #WomensHistoryMonth
Q-Do kidney diseases affect women differently?
2/17
Women have
⬆️Autoimmune diseases (SLE, RA, Systemic Scleroderma)
In #Women of Color that's 2- 3X commoner, early-onset with⬆️ complications
⬆️UTI due to short urethra
In #Pregnancy ⬆️risk of pyelonephritis and sepsis
karger.com/Article/FullTe…
Women have
⬆️Autoimmune diseases (SLE, RA, Systemic Scleroderma)
In #Women of Color that's 2- 3X commoner, early-onset with⬆️ complications
⬆️UTI due to short urethra
In #Pregnancy ⬆️risk of pyelonephritis and sepsis
karger.com/Article/FullTe…
3/17 Pregnancy poses a high risk of #kidney injury due to various etiologies (see pic) which can progress to CKD in the future.
#Preeclampsia is a definite risk factor for #CKD and #ESKD in mother and also for #cardiovascular disease
pubmed.ncbi.nlm.nih.gov/26342729/
#Preeclampsia is a definite risk factor for #CKD and #ESKD in mother and also for #cardiovascular disease
pubmed.ncbi.nlm.nih.gov/26342729/
Excited to see our paper in @JCI_insight! Silver lining of lab shutdown this yr was time to wrap up this project which has been yrs in the making.
We studied a Stox1 KO mouse model to probe mechanisms underlying hypertensive disorders of #pregnancy. 1/
insight.jci.org/articles/view/…
We studied a Stox1 KO mouse model to probe mechanisms underlying hypertensive disorders of #pregnancy. 1/
insight.jci.org/articles/view/…
STOX1 is a TF and predicted #preeclampsia risk gene IDed through family-based genetic linkage studies (van Dijk, @NatureGenet 2005). A variant in the DNA-binding domain was proposed to alter protein function ➡️ preE susceptibility. But LOF model had not been studied. 🐁 2/
*We found that loss of Stox1 ➡️ gHTN assd w placental hypoxia + abnormal ECM deposition.
*We observed activation of the uteroplacental renin-angiotensin system in Stox1 KO mice.
*Treatment w an ARB, losartan, rescued the gHTN phenotype, validating the mechanism. 3/
*We observed activation of the uteroplacental renin-angiotensin system in Stox1 KO mice.
*Treatment w an ARB, losartan, rescued the gHTN phenotype, validating the mechanism. 3/
Very important and high-yield #AIBD2020 session with @UmaMahadevanIBD on #IBD in #pregnancy! 🤰🔥💩👶
⬇️⬇️⬇️
@IBDConference #GITwitter #GI #OBGYNtwitter #OBGYN
⬇️⬇️⬇️
@IBDConference #GITwitter #GI #OBGYNtwitter #OBGYN
Management of a healthy pregnancy begins... before pregnancy!
#AIBD2020 @IBDConference @UmaMahadevanIBD #IBD
#AIBD2020 @IBDConference @UmaMahadevanIBD #IBD
Start planning early!
Want 3 months of steroid-free remission before conception.
#AIBD2020 @IBDConference @UmaMahadevanIBD #IBD
Want 3 months of steroid-free remission before conception.
#AIBD2020 @IBDConference @UmaMahadevanIBD #IBD
Wonderful talk at #AHA10 @MarilynCipolla on #preeclampsia and the Brain #neuroobstetrics #cardioobstetrics @uvmvermont @MaryCushmanMD
🧠Preeclampsia is vascular disorder
🧠Preeclampsia defined below @acog
🧠Once you have PE, greater 🫀 events, HTN, DM
🧠 But also BRAIN effects
🧠Preeclampsia is vascular disorder
🧠Preeclampsia defined below @acog
🧠Once you have PE, greater 🫀 events, HTN, DM
🧠 But also BRAIN effects
#AHA20 #preeclampsia
🤰Preeclampsia is an exaggerated response of pregnancy induced inflammation, hyperlipidemia and hypercoagulation
⬆️ risk of:
🧠seizures
🧠stroke
🧠cognitive decline
🤰Preeclampsia is an exaggerated response of pregnancy induced inflammation, hyperlipidemia and hypercoagulation
⬆️ risk of:
🧠seizures
🧠stroke
🧠cognitive decline
Follow along as we live tweet the @FertStert journal club. What do you think about #uterinetransplant? #ASRM2019
Send your questions via Twitter to ask the panel! #ASRM2019
