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Starting off the day on complex traits. @asiepel assures us he's not @BeEngelhardt but she's late because she's voting! First talk is David Balding #probgen18
DB: begins by explaining LD score regression. Intuition: the more LD a SNP has, the more reach it has, and so test statistics will be bigger. Slope is measure of heritability. Points out that there's binning that can be misleading #probgen18
DB: LD score regression is easy and uses summary statistics so it's very popular. But it's "sort of wrong", slope is not good measure of heritability and intercept is not good measure of confounding #probgen18
