Discover and read the best of Twitter Threads about #proinflammatory

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CVR Tomasz Guzik
@CVR_TomaszGuzik
Endothelial-derived microvesicles play a pathogenic role in vascular #inflammation, causing #endothelial barrier dysfunction by impairing adherens junctions and activating #neutrophils

More here: bit.ly/3g1FpH7
#Cardiotwitter #CardiovascularResearch

#Tweetorial below! Image
#Microvesicles (MV) are formed from the outward blebbing of the plasma membrane and carry a diverse cargo that regulate multiple processes.

During #inflammation these are produced by activated endothelial cells and released into the #circulation. TEM image of plasma MVs: (2/8) Image
In this study the authors investigated whether endothelial-derived MVs (EC-MVs) contribute to #vascular dysfunction during inflammation.

The authors used an animal model of #sepsis (CLP) and found that this increased EC-MV production (3/8) Image
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Related hashtags

#sepsis #Junction #Cardiotwitter #circulation #protein #dysfunction #Microvesicles #proinflammatory #inflammation #Adherens #CardiovascularResearch #phosphorylation #permeability #injury #Tweetorial #vascular #neutrophils #endothelial #cytoskeleton

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